Psychopharmacology

, Volume 68, Issue 3, pp 221–227 | Cite as

Acute and chronic ethanol treatment changes endorphin levels in brain and pituitary

  • Rüdiger Schulz
  • Michael Wüster
  • Theodora Duka
  • Albert Herz
Original Investigations

Abstract

Acute ethanol administration increased methionine-enkephalin (met-enkephalin) and β-endorphin levels in distinct areas of the rat brain, whereas chronically supplied ethanol caused a depression of met-enkephalin and β-endorphin levels in most of the brain areas investigated. The β-endorphin content of the intermediate/posterior lobe of the pituitary of rats and guinea pigs decreased by 70%. Withdrawal of ethanol resulted in a complete recovery of endorphin levels in brain and pituitary within two weeks. Whether the observed alterations in endorphin concentrations are causally related to the primary mechanisms under-lying alcohol dependence is uncertain, since no obvious signs of physical dependence were observed in treated animals.

Key words

Endorphin Enkephalin Ethanol Tolerance/Dependence 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Rüdiger Schulz
    • 1
  • Michael Wüster
    • 1
  • Theodora Duka
    • 1
  • Albert Herz
    • 1
  1. 1.Department of NeuropharmacologyMax-Planck-Institute of PsychiatryMünchen 40Germany

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