, Volume 79, Issue 2–3, pp 137–141 | Cite as

Profile of acute tolerance to three sedative anxiolytics

  • Everett H. EllinwoodJr.
  • Markku Linnoila
  • Martha E. Easler
  • David W. Molter
Original Investigations


Acute tolerance, defined as a decreasing drug effect relative to drug-plasma levels (DPL) over a period of minutes to a few hours, is pronounced following single doses of diazepam or pentobarbital. Both of these lipid-soluble drugs produce an early peak behavioral impairment and subsequent rapid recovery component that is followed by a much slower blood-drug rise time. These pronounced early peak effects were not shared by alcohol, and contribute significantly to the lack of correlation between impairment and DPL.

Key words

Acute tolerance Peak impairment Sedative anxiolytics Plasma concentration 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Everett H. EllinwoodJr.
    • 1
  • Markku Linnoila
    • 1
  • Martha E. Easler
    • 1
  • David W. Molter
    • 1
  1. 1.Behavioral Neuropharmacology Section, Department of PsychiatryDuke University Medical CenterNCDurhamUSA

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