Archives of Dermatological Research

, Volume 280, Issue 8, pp 477–480 | Cite as

Studies of polymorphonuclear migration into psoriatic skin using a new in vivo method

  • B. Guillot
  • M. Coupe
  • M. Alirezai
  • J. P. Bureau
  • J. J. Guilhou
Original Contributions


A new method, employing a skin-implanted cell trap already used to study chemotaxis in cancer patients, was applied to 35 healthy volumteers and 12 psoriatic patients. A dacron disk impregnated with 10 μl of 4–6·106 live BCG suspension was implanted in the deep dermis. After 24 h the disk was removed, and five sections of each disk were counted for polymorphonuclear leukocytes (PMNs) and monocytes. Involved and uninvolved psoriatic skin showed a decrease of PMN migration into the disk as compared with controls. No difference could be demonstrated between involved and uninvolved skin. Mononuclear cell chemotaxis was the same in psoriasis as in controls. These results are in agreement with other in vivo data using mainly the skin chamber technique indicating a decrease of PMN chemotaxis in psoriatic skin at 24 h.

Key words

Polymorphonuclear leukocytes Chemotaxis Psoriasis 


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • B. Guillot
    • 1
  • M. Coupe
    • 1
  • M. Alirezai
    • 1
  • J. P. Bureau
    • 1
  • J. J. Guilhou
    • 1
  1. 1.Service de Dermatologie-PhlébologieHôpital Saint-CharlesMontpellier CedexFrance

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