Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Inverted urinary papilloma

Report of five cases and review of the literature

  • 35 Accesses

  • 51 Citations


Five new cases of inverted urinary papilloma are described and 13 previously reported cases are reviewed. All 18 examples were seen in adult males, with ages ranging from 26 to 79 years (average 57 years). Ten patients presented with symptoms of bladder outlet obstruction and 8 with haematuria. With one probable exception all of the tumours were solitary. Sixteen were found in the region of the bladder neck and prostatic urethra, and only 2 occurred in other sites. The papillomas were pedunculated or sessile and ranged in size from a few mms to 3 cms in greatest diameter. Most had smooth surfaces in contrast to the usual exophytic papillary urothelial neoplasms. Microscopically they showed a striking resemblance to the inverted papillomas of the nasal cavity and paranasal sinuses. In those examples where the stalk or base of the papilloma was included in the sections, there was no evidence of invasion of the underlying smooth muscle. Fourteen of the patients have been followed for periods ranging from 7 months to 11 years (average 2.5 years) and no recurrences have been documented. Simple local resection, by the transurethral route where possible, appears to be adequate treatment for these distinctive papillomas.

This is a preview of subscription content, log in to check access.


  1. Ash, J. E., Beck, M. R., Wilkes, J. D.: Tumors of the upper respiratory tract and ear. In: Atlas of tumor pathology, sect. IV, fasc. 12, p. 32–33. Washington D. C.: Armed Forces Institute of Pathology 1964

  2. Assor, D., Taylor, J. N.: Inverted papilloma of the bladder. J. Urol. (Baltimore) 104, 715–717 (1970)

  3. Blackard, C. E.: Surgical treatment of carcinoma of the bladder. In: Benign and malignant tumors of the urinary bladder, ed. Maltry, E., Jr., p. 112–153. New York: Medical Examination Publishing Co. 1971

  4. Borski, A. A.: Hamartoma of the bladder. J. Urol. (Baltimore) 104, 718–719 (1970)

  5. Borski, A. A.: Personal communication (1974)

  6. Bransilver, B. R., Ferenczy, A., Richart, R. M.: Brenner tumors and Walthard cell nests. Arch. Path. 98, 76–86 (1974)

  7. Cummings, R.: Inverted papilloma of the bladder. J. Path. 112, 225–227 (1974)

  8. Emmett, J. L., McDonald, J. R.: Proliferation of glands of the urinary bladder simulating malignant neoplasm. J. Urol. (Baltimore) 48, 257–265 (1942)

  9. Hardy, E. G., Allen, P. W.: Report of histopathology survey, p. 8–9. Sydney: The Board of Education, The Royal College of Pathologists of Australia 1972

  10. Hirst, E.: Personal communication (1972)

  11. Inada, T., Ochiai, K.: Inverted papilloma of the bladder [Jap.]. Jap. J. Cancer Clin. 17, 774–776 (1971)

  12. Matz, L. R.: Personal communication (1974)

  13. Matz, L. R., Wishart, V. A., Goodman, M. A.: Inverted urothelial papilloma. Pathology 6, 37–44 (1974)

  14. McGovern, V. J.: The histological classification of bladder tumours. Pathology I, 255–264 (1969)

  15. Mostofi, F. K., Leestma, J. E.: Lower urinary tract and male genitalia. In: Pathology, ed. Anderson, W. A. D., 6th ed., p. 828–874 St. Louis: Mosby 1971

  16. Pienkos, E. J., Iglesias, F., Jablokow, V. R.: Inverted papilloma of bladder. Urology 2, 178–179 (1973)

  17. Pyrah, L. N., Raper, F. P., Thomas, G. M.: Report of a follow-up of papillary tumours of the bladder. Brit. J. Urol. 36, 14–25 (1964)

  18. Snyder, R. N., Perzin, K. H.: Papillomatosis of the nasal cavity and paranasal sinuses (inverted papilloma, squamous papilloma). A clinicopathologic study. Cancer (Philad.) 30, 668–690 (1972)

  19. Sullivan, J. J., Watson, J. G., Kingston, C. W., Yaxley, R. P.: Inverted papilloma of the urinary bladder: A report of two cases. Aust. N. Z. J. Surg. 41, 60–62 (1971)

  20. Thackray, A. C.: The urinary passages. In: Systemic pathology, ed. Payling Wright, G., Symmers, W. St. C., 1st ed., p. 769–800. London: Longmans 1966

  21. Trites, A. E. W.: Inverted urothelial papilloma: report of two cases. J. Urol. (Baltimore) 101, 216–219 (1969)

  22. Trites, A. E. W.: Personal communication (1974)

  23. Vidyarthi, S. C.: Pathology of bladder tumors. In: Benign and malignant tumors of the urinary bladder, ed. Maltry, E., Jr., p. 13–36. New York: Medical Examination Publishing Co. 1971

Download references

Author information

Additional information

We are indebted to Drs. A. A. Borski, G. Burfield, P. Hall, L. R. Matz, J. Mill, R. Osmond, A. E. W. Trites and J. Willson for provision of clinical and pathological data. We thank Dr. T. Morizono for translation of the Japanese reference. The photomicrographs were prepared by Mr. H. Upenieks, Department of Medical Illustrations, The University of Western Australia. The manuscript was typed by Mrs. M. P. Grover, Department of Pathology, University of Western Australia.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Henderson, D.W., Allen, P.W. & Bourne, A.J. Inverted urinary papilloma. Virchows Arch. A Path. Anat. and Histol. 366, 177–186 (1975). https://doi.org/10.1007/BF00427408

Download citation

Key words

  • Urinary Tract
  • Bladder
  • Urothelium
  • Inverted Papilloma
  • Transitional Cell Carcinoma