, Volume 85, Issue 1, pp 51–56

Behavioral pharmacokinetics of marijuana

  • Gene Barnett
  • Vojtech Licko
  • Travis Thompson
Original Investigations

DOI: 10.1007/BF00427321

Cite this article as:
Barnett, G., Licko, V. & Thompson, T. Psychopharmacology (1985) 85: 51. doi:10.1007/BF00427321


Male volunteer subjects smoked one marijuana cigarette containing 100, 200, or 250 μg/kg Δ-9-tetrahydrocannabinol (THC) and were tested on three perceptual-motor performance measures related to driving. Performance was measured and blood samples were collected for 24 h after smoking. The covariation between phamacodynamics of performance and pharmacokinetics of THC in plasma was investigated for decrement in performance as the response to smoking a single marijuana cigarette. A significant linear correlation was found between tracking errors under divided attention and THC plasma levels over 5–25 ng/ml for approximately 2 h after smoking. A sigmoid relation was found between critical tracking breakpoint and log THC plasma levels over 2–25 ng/ml for approximately 7 h after smoking.

Key words

Marijuana Human subjects Perceptual-motor performance THC plasma levels Correlation of performance with plasma levels Driving 

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Gene Barnett
    • 1
  • Vojtech Licko
    • 2
  • Travis Thompson
    • 3
  1. 1.Division of Preclinical ResearchNational Institute on Drug AbuseRockvilleUSA
  2. 2.Cardiovascular Research InstituteUniversity of CaliforniaSan FranciscoUSA
  3. 3.Department of PsychologyUniversity of MinnesotaMinneapolisUSA
  4. 4.Laboratory of Mathematical BiologyNational Cancer InstituteBethesdaUSA

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