Acta Neuropathologica

, Volume 84, Issue 1, pp 100–104

Lewy bodies in Parkinson's disease are recognized by antibodies to complement proteins

  • T. Yamada
  • P. L. McGeer
  • E. G. McGeer
Short Original Communications


The substantia nigra (SN) in 11 Parkinson's disease (PD) patients and 5 neurologically normal controls was examined immunohistochemically using antibodies to various proteins of the complement system. In PD, but not in control SN, intra-and extraneuronal Lewy bodies and dendritic spheroid bodies were stained with anti-human C3d, C4d, C7 and C9 antibodies, but not with antibodies to C1q, fraction Bb of factor B or properdin. Axonal spheroid bodies in the nigrostriatal tract were not stained by any of the complement antibodies. However, complement-activated oligodendroglia were revealed by anti-C3d and anti-C4d antibodies in the PD substantia nigral area. These data indicate that some pathological structures in PD activate the classical complement pathway.

Key words

Parkinson's disease Complement Lewy bodies Oligodendrocytes 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • T. Yamada
    • 1
    • 2
  • P. L. McGeer
    • 1
    • 2
  • E. G. McGeer
    • 1
    • 2
  1. 1.Kinsmen Laboratory of Neurological Research, Department of PsychiatryUniversity of British Columbia VancouverCanada
  2. 2.Neurodegenerative Diseases CentreUniversity of British Columbia VancouverCanada
  3. 3.University of B.C.VancouverCanada

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