Acta Neuropathologica

, Volume 84, Issue 1, pp 100–104

Lewy bodies in Parkinson's disease are recognized by antibodies to complement proteins

  • T. Yamada
  • P. L. McGeer
  • E. G. McGeer
Short Original Communications

DOI: 10.1007/BF00427222

Cite this article as:
Yamada, T., McGeer, P.L. & McGeer, E.G. Acta Neuropathol (1992) 84: 100. doi:10.1007/BF00427222

Summary

The substantia nigra (SN) in 11 Parkinson's disease (PD) patients and 5 neurologically normal controls was examined immunohistochemically using antibodies to various proteins of the complement system. In PD, but not in control SN, intra-and extraneuronal Lewy bodies and dendritic spheroid bodies were stained with anti-human C3d, C4d, C7 and C9 antibodies, but not with antibodies to C1q, fraction Bb of factor B or properdin. Axonal spheroid bodies in the nigrostriatal tract were not stained by any of the complement antibodies. However, complement-activated oligodendroglia were revealed by anti-C3d and anti-C4d antibodies in the PD substantia nigral area. These data indicate that some pathological structures in PD activate the classical complement pathway.

Key words

Parkinson's disease Complement Lewy bodies Oligodendrocytes 

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • T. Yamada
    • 1
    • 2
  • P. L. McGeer
    • 1
    • 2
  • E. G. McGeer
    • 1
    • 2
  1. 1.Kinsmen Laboratory of Neurological Research, Department of PsychiatryUniversity of British Columbia VancouverCanada
  2. 2.Neurodegenerative Diseases CentreUniversity of British Columbia VancouverCanada
  3. 3.University of B.C.VancouverCanada

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