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Involvement of gamma-amino butyric acid (GABA) in the anticonvulsant action of methaqualone

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Abstract

The effects of methaqualone on isonicotinic acid hydrazide, 6-mercapto propionic acid, picrotoxin, and strychnine-induced convulsion were studied in mice and the results compared with diazepam. Methaqualone, like diazepam, was found to be a selective antagonist of isoniazid-induced convulsion and a much less effective inhibitor of strychnine convulsion.

Methaqualone elicits muscle-relaxant, sedative, and anticonvulsant effects at different dose levels. At low, nonsedative doses the drug produces anticonvulsant effects, and at higher doses, muscle-relaxant and sedative effects. It appears that the mechanism(s) of action of methaqualone is on GABA deficiency or receptor blockade, rather than on glycine receptors.

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Naik, S.R., Naik, P.R. & Sheth, U.K. Involvement of gamma-amino butyric acid (GABA) in the anticonvulsant action of methaqualone. Psychopharmacology 57, 103–107 (1978). https://doi.org/10.1007/BF00426965

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Key words

  • Isonicotinic acid hydrazide
  • 6-Mercapto propionic acid
  • Picrotoxin
  • strychnine
  • Convulsion
  • GABA