Advertisement

Springer Nature is making Coronavirus research free. View research | View latest news | Sign up for updates

Paradoxical effects in sleep and performance of two doses of chlorpromazine

  • 13 Accesses

  • 6 Citations

Abstract

Twenty-four subjects were given placebo, 25 mg, and 75 mg of chlorpromazine on three separate occasions. Twelve subjects were treated in the morning and tested for performance during the day. Twelve other subjects received the drug treatments in the evening. Both groups had their EEG stages of sleep recorded during the subsequent night. The low dose of drug shortened the REM/non-REM cycle length in comparison to the high dose, and placebo values were intermediate. In performance tests, visual integration time was impaired by the high dose of the drug. Logical reasoning was slowed by the high dose of the drug in comparison to the low dose, with placebo values intermediate between the two.

This is a preview of subscription content, log in to check access.

References

  1. Allport, D. A.: Phenomenal simultaneity and the perceptual moment hypothesis. Br. J. Psychol. 59, 395–406 (1968)

  2. Baddeley, A. D.: A 3-minute reasoning test based on grammatical transformation. Psychon. Sci. 10, 341–342 (1968)

  3. Besser, G. M., Duncan, C.: The time course of action of single doses of diazepam, chlorpromazine and some barbiturates, as measured by auditory flutter fusion and visual flicker fusion thresholds in man. Br. J. Pharmacol. Chemother. 30, 341–348 (1967)

  4. Freemon, F. R.: Clinical pharmacology of sleep: a critical review of all-night electroencephalographic studies. Behav. Neuropsychiatry 5, 49–60 (1973)

  5. Hartley, L. R., Adams, R. G.: Effect of noise on the Stroop Test. J. Exp. Psychol. 102, 62–66 (1974)

  6. Jensen, A. R., Rohwer, W. D., Jr.: The Stroop color-word tests: a review. Acta Psychol 25, 36–93 (1966)

  7. Kornetsky, C., Orzack, M. H.: A research note on some of the critical factors on the dissimilar effects of chlorpromazine and secobarbital on the digit symbol substitution and continuous performance tests. Psychopharmacologia (Berl.) 6, 79–86 (1964)

  8. Lavie, P. M., Levy, M., Coolidge, F. L.: Ultradian rhythms in the perception of the spiral after effect. Physiol. Psychol. 3, 144–146 (1975)

  9. Lehmann, H. E., Csank, J.: Differential screening of phrenotropic agents in man. J. Clin. Exp. Psychopathol. 18, 222–235 (1957)

  10. Lewis, S. A., Evans, J. I.: Dose effects of chlorpromazine on human sleep. Psychopharmacologia (Berl.) 14, 342–348 (1969)

  11. Mirsky, A. F., Rosvold, H. E.: Psychoactive drugs in studies of attention. In: Drugs and behaviour, L. Uhr and J. O. Miller, eds. London: John Wiley 1960

  12. Rappaport, M., Hopkins, H. K.: Signal detection and chlorpromazine. Hum. Factors 13, 387–390 (1977)

  13. Rechtschaffen, A., Kales, A.: A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Washington, D. C.: Public Health Service, U.S. Government Printing Office 1968

  14. Turner, P.: A comparison of fluphenazine and chlorpromazine on critical flicker fusion frequency. J. Pharm. Pharmacol. 18, 836 (1966)

  15. Winer, B. J.: Statistical principles in experimental design. New York: McGraw Hill 1962

Download references

Author information

Correspondence to L. Hartley.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Hartley, L., Couper-Smartt, J. Paradoxical effects in sleep and performance of two doses of chlorpromazine. Psychopharmacology 58, 201–205 (1978). https://doi.org/10.1007/BF00426908

Download citation

Key words

  • Chlorpromazine
  • Sleep stages
  • Human performance
  • Ultradian rhythm