Psychopharmacology

, Volume 49, Issue 3, pp 275–279 | Cite as

Marijuana and ethanol: Differential effects on time perception, heart rate, and subjective response

  • Jared R. Tinklenberg
  • Walton T. Roth
  • Bert S. Kopell
Human Pharmacology

Abstract

Performance on a time production task, heart rate, and subjective responses were studied in twelve male subjects given oral doses of marijuana (0.7 mg of delta-9-tetrahydrocannabinol/kg), ethanol (1.0 ml/kg), and placebo, on three testing days which were each separated by 1 week. Orders were balanced across subjects and testing conditions were doubleblind. Compared to ethanol and placebo, marijuana induced a significant under-production of time intervals, suggesting an acceleration of the internal rate of time perception. The onset of this acceleration of time sense in which geophysical time seemed to pass slowly corresponded with the characteristic increase in heart rate and the onset of the subjective feelings of drug effects. Initial phases of alcohol intoxication were associated with the opposite effects on the time production task. These findings replicate previous work and indicate that an easily administered time production task provides a consistent, non-motor measure of acute marijuana intoxication and also reflects ethanol intoxication.

Key words

Time production Time perception Marijuana Ethanol Heart rate 

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References

  1. Beaconsfield, P., Ginsburg, J., Rainsbury, R.: Marihuana smoking, cardiovascular effects in man and possible mechanisms. new Engl. J. Med. 287, 209–212 (1972)Google Scholar
  2. Bech, P., Rafaelson, L., Rafaelson, O. J.: Cannabis and alcohol: effects on estimation of time and distance. Psychopharmacologia (Berl.) 32, 373–381 (1973)Google Scholar
  3. Cappell, H., Webster, C. D., Herring, B. S., Ginsberg, R.: Alcohol and marijuana: A comparison of effects on a temporally controlled operant in humans. J. Pharmacol. exp. Ther. 182, 195–203 (1972)Google Scholar
  4. Carlini, E. A., Karniol, I. G., Renault, P. F., Schuster, C. R.: Effects of marihuana in laboratory animals and in man. Brit. J. Pharmacol. 50, 299–309 (1974)Google Scholar
  5. Clark, L. D., Hughes, R., Nakashima, E. N.: Behavioral effects of marihuana. Arch. gen. Psychiat. 23, 193–198 (1970)Google Scholar
  6. Clausen, J.: An evaluation of experimental methods of time judgment. J. exp. Psychol. 40, 756–761 (1950)Google Scholar
  7. Dornbush, R. L., Fink, M., Freedman, A. M.: Marijuana, memory and perception. Amer. J. Psychiat. 128, 194–197 (1971)Google Scholar
  8. Fischer, R.: The biological fabric of time. In: Interdisciplinary perspectives of time. Ann. N. Y. Sci. 138, Article 2 (1967)Google Scholar
  9. Frankenhaeuser, M.: Estimation of time, an experimental study. Stockholm: Almqvist and Wiksell 1959Google Scholar
  10. Goldstone, S., Boardman, W. K., Lhamon, W. T.: Effect of quinal barbitone, dextroamphetamine, and placebo on apparent time. Brit. J. Psychiat. 49, 324 (1958)Google Scholar
  11. Hollister, L. E., Gillespie, H. K.: Marijuana, ethanol and dextroamphetamine: Mood and mental function alterations. Arch. gen. Psychiat. 23, 199–203 (1970)Google Scholar
  12. Hollister, L. E., Tinklenberg, J. R.: Subchronic oral dose of marijuana extract. Psychopharmacologia (Berl.) 29, 247–252 (1973)Google Scholar
  13. Isbell, H., Gorodetzsky, C. W., Jasinski, D., Claussen, U., Spulak, F. V., Korte, F.: Effects of (−)Δ9, Transtetrahydrocannabinol in man. Psychopharmacologia (Berl.) 11, 184–188 (1967)Google Scholar
  14. Jones, R. T., Stone, G. C.: Psychological studies of marijuana and alcohol in man. Psychopharmacologia (Berl.) 18, 108–117 (1970)Google Scholar
  15. Kiplinger, G. F., Manno, J. E., Rodda, B. E., Forney, R. B.: Dose-response analysis of the effects of tetrahydrocannabinol in man. Clin. Pharmacol. Ther. 12, 650–657 (1971)Google Scholar
  16. Kopell, B. S., Wittner, W. K., Lunde, D., Warrick, G., Edwards, D.: Cortisol effects on averaged evoked potential, alpha-rhythm, time estimation, and two-flash fusion threshold. Psychosom. Med. 32, 39–49 (1970)Google Scholar
  17. Kopell et al., in preparation: Time action effects of marijuana and alcohol on event related potentials in man.Google Scholar
  18. Melges, F. T., Tinklenberg, J. R., Deardorff, C. M., Davies, N. H., Anderson, R. E., Owen, C. A.: Temporal disorganization and delusional-like ideation. Arch. gen. Psychiat. 30, 855–861 (1974)Google Scholar
  19. Melges, F. T., Tinklenberg, J. R., Hollister, L. E., Gillespie, H. K.: Marijuana and temporal disintegration. Science 168, 1118–1120 (1970a)Google Scholar
  20. Melges, F. T., Tinklenberg, J. R., Hollister, L. E., Gillespie, H. K.: Temporal disintegration and depersonalization during marijuana intoxication. Arch. gen. Psychiat. 23, 204–210 (1970b)Google Scholar
  21. Melges, F. T., Tinklenberg, J. R., Hollister, L. E., Gillespie, H. K.: Marijuana and the temporal span of awareness. Arch. gen. Psychiat. 24, 564–567 (1971)Google Scholar
  22. Meyer, R. E., Pillard, R. C., Shapiro, L. M., Mirin, S. M.: Administration of marijuana to heavy and casual marijuana users. Amer. J. Psychiat. 128, 198–204 (1971)Google Scholar
  23. Ornstein, R. E.: On the experience of time. Baltimore: Penguin Books 1969Google Scholar
  24. Robson, J. G., Burns, B. D., Welt, P. J. L.: The effect of inhaling diluted nitrous oxide. Canad. Anaesth. Soc. J 7, 399–410 (1960)Google Scholar
  25. Roth, W. T., Kopell, B. S., Tinklenberg, J. R., Huntsberger, G. E., Kraemer, H. C.: Reliability of the contingent negative variation and the auditory evoked potential. Electroenceph. clin. Neurophysiol. 38, 45–50 (1975)Google Scholar
  26. Rossi, A. M., O'Brien, J.: Memory and time estimation. In: The use of marijuana, J. H. Mendelson, A. M. Rossi, and R. E. Meyer, eds. New York: Plenum Press 1974Google Scholar
  27. Rutschmann, J., Rubinstein, L.: Time estimation, knowledge of results, and drug effects. Psychiat. Res. 4, 107–114 (1966)Google Scholar
  28. Tinklenberg, J. R., Darley, C. F.: Psychological and cognitive effects of cannabis. In: Cannabis and man: Psychological and clinical aspects and patterns of use, P. H. Connell and N. Dorn, eds, New York:Churchill, Livingstone 1975Google Scholar
  29. Tinklenberg, J. R., Darley, C. F.: A model of marijuana's cognitive effects. In: Pharmacology of marijuana, M. C. Braude and S. Szara, eds. New York: Raven Press (1976)Google Scholar
  30. Tinklenberg, J. R., Kopell, B. S., Melges, F. T., Hollister, L. E.: Marijuana and alcohol: time production and memory function. Arch. gen. Psychiat. 27, 812–815 (1972)Google Scholar
  31. Vachon, L., Sulkowski, A., Rich, E.: Marihuana effects on learning, attention, and time estimation. Psychopharmacologia (Berl.) 39, 1–11 (1974)Google Scholar
  32. Weil, A. T., Zinberg, N. E., Nelson, J. M.: Clinical and psychological effects of marihuana in man. Science 162, 1234–1242 (1968)Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Jared R. Tinklenberg
    • 1
    • 2
  • Walton T. Roth
    • 1
    • 2
  • Bert S. Kopell
    • 1
    • 2
  1. 1.Laboratory of Clinical Psychopharmacology and Psychophysiology, Department of Psychiatry and Behavioral SciencesStanford University School of MedicineStanfordUSA
  2. 2.Veterans Administration HospitalPalo AltoUSA

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