Psychopharmacology

, Volume 52, Issue 1, pp 73–77

Clinical pharmacological studies of tandamine, a potential antidepressive drug

  • Raihana S. B. Ehsanullah
  • Karabi Ghose
  • Marilyn J. Kirby
  • P. Turner
  • D. Witts
Human Pharmacology

DOI: 10.1007/BF00426603

Cite this article as:
Ehsanullah, R.S.B., Ghose, K., Kirby, M.J. et al. Psychopharmacology (1977) 52: 73. doi:10.1007/BF00426603

Abstract

Tandamine hydrochloride, a thiopyranoindole, was more active than desmethylimipramine in inhibiting the tyramine pressor response after single oral doses in human volunteers. When compared with a placebo, tandamine was found to possess significant anticholinergic activity, to reduce appetite and to produce sedation. Compared with clomipramine, it caused a smaller inhibition of 5-HT but a more marked inhibition of dopamine uptake into human platelets. Further clinical and pharmacological studies with tandamine may help to elucidate the respective roles of different monoamines in depression, sedation and appetite.

Key words

Tandamine Tyramine pressor response Anticholinergic Appetite Sedation Depression Platelet Plasma concentration Monoamines 

Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Raihana S. B. Ehsanullah
    • 1
  • Karabi Ghose
    • 1
  • Marilyn J. Kirby
    • 1
  • P. Turner
    • 1
  • D. Witts
    • 1
  1. 1.Department of Clinical PharmacologySt. Bartholomew's HospitalLondonEngland

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