Comparative Haematology International

, Volume 2, Issue 3, pp 175–178 | Cite as

Amegakaryocytic thrombocytopenia and immune-mediated haemolytic anaemia in a cat

  • F. P. Gaschenl
  • B. Smith Meyer
  • John W. Harvey
Case Report


An eleven-month-old female spayed domestic shorthair cat was presented for investigation of pruritic skin lesions and haemorrhage. Haematological evaluation revealed a markedly regenerative anaemia, neutrophilia with left shift, monocytosis, basophilia and severe thrombocytopenia. The direct antiglobulin test and serum antinuclear antibody tests were positive. Serologic and immunofluorescent antibody tests for feline leukaemia virus were negative. Bone marrow cytology revealed a lack of megakaryocytes with erythroid and myeloid hyperplasia. A peritoneopericardial diaphragmatic hernia was detected ultrasonographically, but was not considered to be related to the haematologic abnormalities. An immune-mediated aetiology for the amegakaryocytic thrombocytopenia was considered likely based on the concomitant positive direct antiglobulin and antinuclear antibody tests, but the cat responded poorly to short-term immunosuppressive therapy and was euthanized.


Amegakaryocytic thrombocytopenia Cat Haemolytic anaemia Immune-mediated diseases 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Adelstein DJ, Hines JD (1985) Bone marrow morphologic changes after combination chemotherapy including VP-16 Cancer 56:467–471Google Scholar
  2. Beale K (1988) Azathioprine for treatment of immune-mediated diseases of dogs and cats. J Am Vet Med Assoc 192:1316–1318Google Scholar
  3. Boggs DR, Athens JW, Haab OP, Cancilla PA, Raab SO, Cartwright GE, Wintrobe MM (1964) Leukokinetic studies, VII. Morphology of the bone marrow and blood of dogs given vinblastine sulfate. Blood 23:53–67Google Scholar
  4. Chabner BA, Meyers CE, Olivierio VT (1977) Clinical pharmacology of anticancer drugs. Semin Oncol4:165–179Google Scholar
  5. Faircloth JC, Montgomery JK (1981) Systemic lupus erythematosus in a cat presenting with autoimmune hemolytic anemia. Feline Pract 11(2):22–26Google Scholar
  6. Feldman BF (1989) Disorders of platelets. In: Kirk RW (ed) Current veterinary therapy X. Small animal practice. WB Saunders, Philadelphia, pp 457–465Google Scholar
  7. Gabbert NH (1983) Systemic lupus erythematosus in a cat with thrombocytopenia. Vet Med Small Anim Clinician 78:77–79Google Scholar
  8. Halliwell REW, Gorman NT (1989) Autoimmune blood diseases. In: Halliwell REW, Gorman NT (eds) Veterinary clinical immunology. WB Saunders, Philadelphia, pp 308–336.Google Scholar
  9. Harris RA, Pennington DG (1984) The effects of low-dose vincristine on megakaryocyte colony-forming cells and megakaryocyte ploidy. Br J Haematol 57:37–48Google Scholar
  10. Hart JW, Hartley-Asp B (1983) Induction of micronuclei in the mouse. Revised timing of the final stages of erythropoiesis. Mutat Res 120:127–132Google Scholar
  11. Harvey JW (1981) Myeloproliferative disorders in dogs and cats. Vet Clin North Am Small Anim Pract 11:349–381Google Scholar
  12. Heise SC, Smith RS, Schalm OW (1973) Lupus erythematosus with hemolytic anemia in a cat. Feline Pract 3(3):14–19Google Scholar
  13. Jain NC (1986) Schalm's veterinary hematology, 4th ed, Lea & Febiger, Philadelphia, p 382Google Scholar
  14. Jain NC, Switzer JW (1981) Autoimmune thrombocytopenia in dogs and cats. Vet Clin North Am Small Anim Pract 11:421–435Google Scholar
  15. Joshi BC, Raplee RG, Powell AL, Hancock F (1979) Autoimmune thrombocytopenia in a cat. J Am Anim Hosp Assoc 15:585–588Google Scholar
  16. Manoharan A, Williams NT, Sparrow R (1989) Acquired amegakaryocytic thrombocytopenia: report of a case and review of the literature. Q J Med 70:243–252Google Scholar
  17. Murtaugh RJ, Jacobs RM (1985) Suspected immune-mediated megakaryocytic hypoplasia or aplasia in a dog. J Am Vet Med Assoc 186:1313–1315Google Scholar
  18. Ogilvie GK, Felsburg PJ, Harris CW (1988) Short-term effect of cyclophosphamide and azathoiprine on selected aspects of the canine blastogenic response. Vet Immunol Immunopathol 18:119–127Google Scholar
  19. Pedersen N (1987) Basic and clinical immunology. In: Holzworth J (ed) Diseases of the cat. WB Saunders, Philadelphia, pp 146–181Google Scholar
  20. Penny RHC (1974) The bone marrow of the dog and cat. J Small Anim Pract 15:553–562Google Scholar
  21. Peterson ME, Hurvitz AI, Leib MS, Cavanaugh PG, Dutton RE (1984) Propylthiouracil-associated hemolytic anemia, thrombocytopenia and antinuclear antibodies in cats with hyperthyroidism. J Am Vet Med Assoc 184:806–808Google Scholar
  22. Schalm, OW (1985) Autoimmune hemolytic anemia in the dog. Canine Pract 2:37–45Google Scholar
  23. Scott DW, Haupt KH, Knowlton BF, Lewis RM (1979) A glucocorticoid-responsive dermatitis in cats, resembling systemic lupus erythematosus in man. J Am Anim Hosp Assoc 15:157–171Google Scholar
  24. Thompson JP (1989) Antineoplastic agents in cancer therapy. In: Kirk RW (ed) Current veterinary therapy X. Small animal practice. WB Saunders, Philadelphia, pp 472–475Google Scholar
  25. Werner LL, Gorman NT (1984) Immune-mediated disorders of cats. Vet Clin North Am Small Anim Pract 14:1039–1064Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • F. P. Gaschenl
    • 1
  • B. Smith Meyer
    • 2
  • John W. Harvey
    • 3
  1. 1.Department of Small Animal Clinical Sciences, College of Veterinary MedicineUniversity of FloridaUSA
  2. 2.Comparative and Experimental Pathology, College of Veterinary MedicineUniversity of FloridaUSA
  3. 3.Physiological Sciences, College of Veterinary MedicineUniversity of FloridaUSA

Personalised recommendations