Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Sezary syndrome in a dog

  • 46 Accesses

  • 1 Citations


Sézary syndrome was diagnosed in a dog with epidermotropic lymphosarcoma and a leukaemic blood picture wherein 73.5% of the leucocytes (15582 of 21200 leucocytes /µl of blood) were large mononuclear cells with markedly convoluted nuclei. The dog had a history of multiple skin tumours progressing to hepatosplenomegaly and lymphadenopathy. Alpha-naphthyl acetate esterase staining of blood smears and splenic imprints revealed a focal to multifocal pattern of cytoplasmic enzyme activity that resisted sodium fluoride inibition, indicating that the neoplastic mononuclear cells were T lymphocytes. The neoplastic cells were negative for Sudan black B staining, myeloperoxidase activity, and chloroacetate esterase activity. Ultrastructurally, these cells had convoluted to cerebriform nuclei, 1 to 2 nucleoli, scattered mitochondria, numerous free ribosomes, and a few profiles of rough endoplasmic reticulum. Histological study of tissues collected at necropsy revealed infiltration of the skin, lymph nodes, spleen, liver, and bone marrow with neoplastic lymphocytes.

This is a preview of subscription content, log in to check access.


  1. Ackerman L (1984) Oral T cell-like lymphoma in a dog. J Am Anim Hosp Assoc 20:955–958

  2. Bessis M (1977) In: Blood smears reinterpreted. Springer-Verlag, New York, p 148

  3. Brown NO, Nesbitt GH, Patniak AK et al. (1980) Cutaneous lymphosarcoma in the dog: a disease with variable clinical and histologic manifestations. J Am Anim Hosp Assoc 16:565–572

  4. DeBoer DJ, Turrel JM, Moore PF (1990) Mycosis fungoides in a dog: demonstration of T-cell specificity and response to radiotherapy. J Am Anim Hosp Assoc 26:566–572

  5. Doe R, Zackheim HS, Hill JR (1988) Canine epidermotropic cutaneous lymphoma. Am J Dermatopathol 10:80–86

  6. Johnson JA, Patterson JM (1981) Canine epidermotropic lymphoproliferative disease resembling pagetoid reticulosis in man. Vet Pathol 18:487–493

  7. Kelly DF, Halliwell REW, Schwartzman RM (1972) Generalized cutaneous eruption in a dog, with histological similarity to human mycosis fungoides. Br J Dermatol 86:164–171

  8. Madewell BR, Munn RJ (1990) Canine lymphoproliferative disorders. An ultrastructural study of 18 cases. J Vet Intern Med 4:63–70

  9. McKeever PJ, Grindem CB, Stevens JB et al. (1982) Canine cutaneous lymphoma. J Am Vet Med Assoc 180:531–536

  10. Moore PF, Olivry T (1994) Cutaneous lymphomas in companion animals. Clin Dermatol 12:499–505

  11. Moore PF, Olivry T, Naydan D (1994) Canine cutaneous epitheliotropic lymphoma (mycosis fungoides) is a proliferative disorder of CD8+ T cells. Am J Pathol 2:421–429

  12. Preesman AH, Toonstra J, Van Der Putte SCJ et al. (1993) Immunophenotyping on simultaneously occurring plaques and tumours in mycosis fungoides and Sézary syndrome. Br J Dermatol 129:660–666

  13. Ralfkiaer E, Wollf-Sneedorff A, Thomsen K et al. (1993) Immunophenotypic studies in cutaneous T-cell lymphomas: clinical implications. Br J Dermatol 129:655–659

  14. Sausville EA, Eddy JL, Makuch RW et al. (1988) Histopathologic staging at initial diagnosis of mycosis fungoides and the Sézary syndrome. Definition of three distinctive prognostic groups. Ann Intern Med 109:372–382

  15. Shadduck JA, Reedy L, Lawton G et al. (1978) A canine cutaneous lymphoproliferative disease resembling mycosis fungoides in man. Vet Pathol 15:716–724

  16. Slater DN (1987) Recent developments in cutaneous lymphoproliferative disorders. J Pathol 153:5–19

  17. Thrall MA, Macy DW, Snyder SP et al. (1984) Cutaneous lymphosarcoma and leukemia in a dog resembling Sézary syndrome in man. Vet Pathol 21:182–186

  18. Vonderheid EC, Sobel EL, Nowell PC et al. (1985) Diagnostic and prognostic significance of Sézary cells in peripheral blood smears from patients with cutaneous T cell lymphoma. Blood 66:358–366

  19. Wellman ML, Couto CG, Starkey RJ et al. (1989) Lymphocytosis of large granular lymphocytes in three dogs. Vet Pathol 26:158–163

  20. Wilcock BP, Yager JA (1989) The behavior of epidermotropic lymphoma in twenty-five dogs. Can Vet J 30:754–756

  21. Wulff JC, Sale GE, Deeg HJ et al. (1981) Nonspecific acid esterase activity as a marker for canine T lymphocytes. Exp Hematol 9:865–870

  22. Yam LT, Li CY, Crosby WH (1971) Cytochemical identification of monocytes and granulocytes. Am J Clin Pathol 26:283–290

  23. Zenoble RD, George JW (1980) Mycosis fungoides-like disease in a dog. J Am Anim Hosp Assoc 16:203–208

Download references

Author information

Correspondence to Dr K. S. Latimer.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Latimer, K.S., Rakich, P.M. Sezary syndrome in a dog. Comparative Haematology International 6, 115–119 (1996).

Download citation


  • Alpha naphthyl acetate esterase
  • Cytochemical staining
  • Dog
  • Epidermotropic lymphosarcoma
  • Leukaemic blood picture
  • Sézary syndrome