Molecular and General Genetics MGG

, Volume 201, Issue 2, pp 347–350

Amplification of the ArgF region in strain HfrP4X of E. coli K-12

  • A. P. Jessop
  • C. Clugston
Short Communication

DOI: 10.1007/BF00425683

Cite this article as:
Jessop, A.P. & Clugston, C. Molec. Gen. Genet. (1985) 201: 347. doi:10.1007/BF00425683


In E. coli K-12 the argF gene is flanked by ISI sequences in direct repeat. Mutants that overproduce the argF-coded enzyme ornithine transcarbamylase can be selected; we have shown that in one class of these mutants there is an approximately forty five-fold amplification of the region bounded by the ISI repeats. This class of mutants has been detected only in strains in which the F-factor is integrated in cis to the region.

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • A. P. Jessop
    • 1
  • C. Clugston
    • 1
  1. 1.Department of GeneticsUniversity of GlasgowGlasgowScotland, UK

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