Amplification of the ArgF region in strain HfrP4X of E. coli K-12
- Cite this article as:
- Jessop, A.P. & Clugston, C. Molec. Gen. Genet. (1985) 201: 347. doi:10.1007/BF00425683
In E. coli K-12 the argF gene is flanked by ISI sequences in direct repeat. Mutants that overproduce the argF-coded enzyme ornithine transcarbamylase can be selected; we have shown that in one class of these mutants there is an approximately forty five-fold amplification of the region bounded by the ISI repeats. This class of mutants has been detected only in strains in which the F-factor is integrated in cis to the region.