Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

The recombinational analysis of aberrations and the position of the Notch locus on the polytene chromosome of Drosophila

Summary

The recombinational analysis of heterozygotes for a point-mutant N and a deficiency N suggests that the map region approximated by the interval fa to nd 2 is at the right edge of salivary band 3C7 or in the interband to the right. The map region N 55ell to fa can be anywhere between the left interband and the right edge of 3C7. We discovered that small inversions also can be used in the recombinational analysis, and the inversion data support the conclusions already described.

The reactivation of latent mutability in a Notch inversion resulted in reinversion of the original aberration, followed by reversion of N to N +. From the same Notch inversion, we isolated a spontaneous deficiency superimposed upon the original aberration, which supported our hypothesis that two of our w to N deficiencies probably originated as deficiencies superimposed upon inversions.

This is a preview of subscription content, log in to check access.

References

  1. Green MM (1967) The genetics of a mutable gene at the white locus of Drosophila melanogaster. Genetics 56:467–482

  2. Grell RF (1962) A new model for secondary nondisjunction: The role of distributive pairing. Genetics 47:1737–1754

  3. Jamrich M, Greenleaf AL, Bautz CKF (1977) Localization of RNA polymerase in polytene chromosomes of Drosophila melanogaster. Proc Natl Acad Sci USA 74:2079–2083

  4. Keppy DO, Welshons WJ (1977) The cytogenetics of a recessive visible mutant associated with a deficiency adjacent to the Notch locus in Drosophila melanogaster. Genetics 85:497–506

  5. Keppy DO, Welshons WJ (1980) The synthesis of compound bands in Drosophila melanogaster salivary gland chromosomes. Chromosoma (Berl.) 76:191–200

  6. Lefevre G, Jr (1952) Dp(1,2)w 51b7. Drosophila Inform. Serv 26:66

  7. Lefevre G, Jr, Green MM (1972) Genetic duplication in the white-split interval of the X chromosome in Drosophila melanogaster. Chromosoma (Berl) 36:391–412

  8. Lefevre G, Jr, Kelley J (1972) Strawberry vs. facet-glossy, a locus correction. Drosophila Inform Serv 48:146–147

  9. Lindsley DL, Grell EH (1968) Genetic variations of Drosophila melanogaster. Carnegie Inst Washington Publ 627

  10. Roberts P (1962) Interchromosomal effects and the relation between crossingover and nondisjunction. Genetics 47:1691–1709

  11. Shellenbarger DL, Mohler JD (1975) Temperature sensitive mutations of the Notch locus in Drosophila melanogaster. Genetics 81:143–162

  12. Shellenbarger DL, Mohler JD (1978) Temperature-sensitive periods and autonomy of pleiotropic effects of l(1)N ts-1, a conditional Notch lethal in Drosophila. Dev Biol 62:432–446

  13. Sorsa V, Green MM, Beermann W (1973) Cytogenetic fine structure and the chromosomal localization of the white gene in Drosophila melanogaster. Nature (London) New Biol 245:34–37

  14. Welshon WJ (1974) The cytogenetic analysis of a fractured gene in Drosophila. Genetics 76:775–794

  15. Welshons WJ, Keppy DO (1975) Intragenic deletions and salivary band relationships in Drosophila. Genetics 80:143–155

  16. Zhimulev IF, Belyaeva ES (1975) 3H-uridine labelling patterns in the Drosophila melanogaster salivary gland chromosomes X, 2R and 3L. Chromosoma (Berl.) 49:219–231

Download references

Author information

Correspondence to W. J. Welshons.

Additional information

Communicated by M.M. Green

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Welshons, W.J., Keppy, D.O. The recombinational analysis of aberrations and the position of the Notch locus on the polytene chromosome of Drosophila. Molec. Gen. Genet. 181, 319–324 (1981). https://doi.org/10.1007/BF00425605

Download citation

Keywords

  • Polytene Chromosome
  • Recombinational Analysis
  • Inversion Data
  • Latent Mutability
  • Notch Locus