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Axenomycins, new anthelmintic, antiprotozoal and antifungal antibiotics, produced by Streptomyces lisandri nov. sp.

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From a soil sample a new microorganism was isolated, described and identified as Streptomyces lisandri nov. sp. In submerged fermentation in a suitable culture medium this streptomycete produces three new related compounds, axenomycins A, B and D. Data on the anthelmintic, antiprotozoal and antifungal activities in vitro are reported.

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  1. Arcamone, F., Barbieri, W., Franceschi, G., Penco, S., Vigevani, A.: Axenomycins. I. The structure of chromophore and sugar moieties. J. Amer. chem. Soc. 95, 2008–2009 (1973a)

  2. Arcamone, F., Franceschi, G., Gioia, B., Penco, S., Vigevani, A.: Axenomycins. II. The structure of axenolide. J. Amer. chem. Soc. 95, 2009–2011 (1973b)

  3. Baldacci, E.: Development in the classification of actinomycetes. G. Microbiol. 6, 10–27 (1958)

  4. Baldacci, E., Giolitti, G., Küster, E., Scotti, T.: Rilievi su alcuni caratteri colturali (dimensioni delle colonie, colori dei miceli) nelle colonie di Attinomiceti in relazione all'impiego di vari substrati ed alle modalità di conservazione. G. Microbiol. 9, 33–55 (1961)

  5. Cassinelli, G., Cotta, E., D'Amico, G., Della Bruna, C., Grein, A., Mazzoleni, R., Ricciardi, M. L., Tintinelli, R.: Thaimycins, new anthelmintic and antiprotozoal antibiotics produced by Streptomyces michighanensis var. amylolyticus var. nova. Arch. Mikrobiol. 70, 197–210 (1970)

  6. Della Bruna, C., Ricciardi, M. L., Sanfilippo, A.: Axenomycins, new cestocidal antibiotics. Antimicrobial Agents and Chemotherapy 3, 708 (1973)

  7. Ettlinger, L., Corbaz, R., Hütter, R.: Zur Arteinteilung der Gattung Steptomyces Waksman et Henrici. Arch. Mikribiol. 31, 326–358 (1958)

  8. Flaig, W., Kutzner, H. J.: Beitrag sur Systematik der Gattung Streptomyces Waksman et Henrici. Arch. Mikrobiol. 35, 105–138 (1960)

  9. Gause, G. F., Preobrazhenskaya, T. P., Kudrina, E. C., Blinov, N. M., Riabova, D., Sveshnikova, M. A.: Zur Klassifizierung der Actinomyceten: Jena: Fischer 1958

  10. Gordon, R. D., Smith, M. L.: Proposed group of characters for the separation of Streptomyces and Nocardia. J. Bact. 69, 147–150 (1955)

  11. Grein, A., Spalla, C., Cotta, E.: Streptomyces fradiae var. italicus, a new microorganism which produces the antibiotic aminosidine. G. Microbiol. 13, 299–305 (1965).

  12. Hoffman, W. S.: A rapid photoelectric method for the determination of glucose in blood and urine. J. biol. Chem. 120, 51–55 (1937)

  13. Hütter, R.: Systematik der Streptomyceten. Bibliotheca Microbiologica, Fasc. 6. Basel: Karger 1967

  14. Kada, T., Douvney, C. S., Haas, F. L.: Mutation frequency response of irradiated bacteria to a second radiation exposure. Mutation Res. 3, 118–128 (1966)

  15. Lamy, L.: Intérêt de l'utilization de milieux de composition différent pour la culture de protozoaries parasites. Ann. Inst. Pasteur 98, 761–765 (1960)

  16. Pavlova, E. A.: Sur les méthodes de la culture d'Entamoeba histolytica. Med. Parasit. Parasitic Dis. Moscow 7, 224 (1938)

  17. Pridham, T. G., Anderson, P., Foley, C., Lindenfelser, L. A., Hesseltine, C. W., Benedict, R. G.: A selection of media for maintenance and taxonomic studies of Streptomyces. Antibiot. Ann. 1956/1957, 947–953

  18. Pridham, T. G., Gottlieb, D.: The utilization of carbon compounds by some Actinomycetales as an aid for species determination. J. Bact. 56, 107–114 (1948)

  19. Pridham, T. G., Hesseltine, C. W., Benedict, R. G.: A guide for the classification of Streptomyces according to selected groups. Appl. Microbiol. 6, 52–79 (1958)

  20. Raynaud, M.: Dosage de l'ammoniaque dans les milieux biologiques. Bull. Soc. Chim. biol. (Paris) 30, 713–715 (1948)

  21. Tresner, H. D., Danga, F.: Hydrogen sulfide production by streptomycetes as a criterion for species determination. J. Bact. 76, 239–244 (1958)

  22. Waksman, S. A.: The actinomycetes, Vol. II. Baltimore: Wilkins 1961

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Bianchi, M., Cotta, E., Ferni, G. et al. Axenomycins, new anthelmintic, antiprotozoal and antifungal antibiotics, produced by Streptomyces lisandri nov. sp.. Arch. Microbiol. 98, 289–299 (1974). https://doi.org/10.1007/BF00425290

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Key words

  • Taxonomy
  • Streptomyces
  • Fermentation
  • Antibiotic
  • Anthelmintic
  • Antiprotozoal
  • Antifunga
  • Cestocides
  • Axenomycins
  • Macrolide