Agglutination of vertebrate erythrocytes by strains of newcastle disease and fowl-plague viruses
The behaviour of erythrocytes collected from different individuals of any one animal species, with regards their agglutinability by a specific virus strains was, more or less, similar. A few exceptions to the above rule were observed in which the erythrocytes from one individual behaved in a distinctly different manner from those of other individuals of the same animal species.
Closely related strains of one and the same virus vary widely in their powers of agglutinating erythrocytes of various animal species; one strain may fail completely to agglutinate red blood cells of a certain animal easily agglutinated by the other. Such differences in the agglutinability of red blood cells are, of course more pronounced between different viruses than between strains of one and the same virus.
The agglutination of erythrocytes of different animal species thus serves as a quick means of identifying and separating different viruses as well as different strains of one and the same virus. Several examples supporting this view were cited and discussed.
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