Thyroid and testicular hormone responses to graded and prolonged exercise in man

  • H. Galbo
  • L. Hummer
  • I. B. Petersen
  • N. J. Christensen
  • N. Bie
Article

Abstract

Eight men were studied during graded (47, 77 and 100% of maximal oxygen uptake) and prolonged (76%) exhaustive treadmill running. Plasma catecholamine levels increased progressively with intensity and duration of exercise. Serum concentrations of thyroid-stimulating hormone (TSH) increased with increasing work loads and were 107 (58–243)% (P<0.001) above resting values after maximal work. Thyroxine, triiodothyronine and luteinizing hormone in serum never changed significantly. While a small increase in testosterone concentrations (13 [1–24]%) after maximal exercise probably could be explained by changes in plasma volume, a definite increase (31 [14–56]%) occurred after 40 min of prolonged exercise. During continued exercise testosterone concentrations then gradually declined. Testicular stimulation by the increased catecholamine concentrations possibly contributed to the rise in testosterone concentrations, but no evidence was found for a direct catecholamine induced increase in the activity of the thyroid gland. The exercise induced increase in TSH levels possibly explains the increased thyroid hormone secretion rate, which previously has been found in individuals participating in physical training programs.

Key words

Catecholamines Epinephrine Norepinephrine Luteinizing hormone Thyroid-stimulating hormone 

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References

  1. 1.
    Balsam, A., Leppo, L. E.: Effect of physical training on the mtabolism of thyroid hormones in man. J. appl. Physiol. 38, 212–215 (1975)Google Scholar
  2. 2.
    Christensen, N. J.: Plasma noradrenaline and adrenaline in patients with thyrotoxicosis and myxedema. Clin. Sci. 45, 163–171 (1973)Google Scholar
  3. 3.
    Dufau, M. L.: Radioimmunoassay of plasma testosterone. Clin. chim. Acta 37, 109–114 (1972)Google Scholar
  4. 4.
    Eik-Nes, K. B.: On the relationship between testicular blood flow and secretion of testosterone in anesthetized dogs stimulated with human chorionic gonadotrophin. Canad. J. Physiol. Pharmacol. 42, 671–677 (1964)Google Scholar
  5. 5.
    Eik-Nes, K. B.: Production and secretion of testicular steroids. Recent Progr. Hormone Res. 27, 517–535 (1971)Google Scholar
  6. 6.
    Engelman, K., Portnoy, B.: A sensitive double-isotope derivative assay for norepinephrine and epinephrine. Circulat. Res. 26, 53–57 (1970)Google Scholar
  7. 7.
    Gharib, H., Ryan, R. J., Mayberry, W. E., Hockert, T.: Radioimmunoassay for triiodothyronine (T3). J. clin. Endocr. 33, 509–516 (1971)Google Scholar
  8. 8.
    Hall, R., Amos, J., Ormston, B. J.: Radioimmunoassay of serum thyrotropin. Brit. med. J. 1, 582–585 (1971)Google Scholar
  9. 9.
    Hummer, L., Dige-Petersen, H.: The reliability of normal series based on sera from blood donors (Radioimmunoassay of serum thyroxine). Proceedings of the XIII. International Ann. Meeting Soc. Nucl. Med. 1975Google Scholar
  10. 10.
    Irvine, C. H. G.: Effect of exercise on thyroxine degradation in athletes and non-athletes. J. clin. Endocr. 28, 942–948 (1968)Google Scholar
  11. 11.
    Melander, A., Nilsson, E., Sundler, F.: Sympathetic activation of thyroid hormone secretion in mice. Endocrinology 90, 194–199 (1972)Google Scholar
  12. 12.
    Melander, A., Ericson, L. E., Ljunggren, J.-G., Norberg, K.-A., Persson, B., Sundler, F., Tibblin, S., Westgren, U.: Sympathetic innervation of the normal human thyroid. J. clin. Endocr. 39, 713–718 (1974)Google Scholar
  13. 13.
    Melander, A., Ranklev, E., Sundler, F., Westgren, U.: Beta2-adrenergic stimulation of thyroid hormone secretion. Endocrinology 97, 332–336 (1975)Google Scholar
  14. 14.
    Odell, W. D., Ross, G. T., Rayford, P. L.: Radioimmunoassay for luteinizing hormone in human plasma or serum. Physiological studies. J. clin. Invest. 46, 248–255 (1967)Google Scholar
  15. 15.
    Rowell, L. B.: Human cardiovascular adjustments to exercise and thermal stress. Physiol. Rev. 54, 75–159 (1974)Google Scholar
  16. 16.
    Story, J. A., Griffith, D. R.: Effect of exercise on thyroid hormone secretion rate in aging rats. Horm. Metab. Res. 6, 403–406 (1974)Google Scholar
  17. 17.
    Sutton, J. R., Coleman, M. J., Casey, J., Lazarus, L.: Androgen responses during physical exercise. Brit. med. J. 1, 520–522 (1973)Google Scholar
  18. 18.
    Terjung, R. L., Tipton, C. M.: Plasma thyroxine and thyroid-stimulating hormone levels during submaximal exercise in humans. Amer. J. Physiol. 220, 1840–1845 (1971)Google Scholar
  19. 19.
    Weeke, J.: Circadian variation of the serum thyrotropin level in normal subjects. Scand. J. clin. Lab. Invest. 31, 337–342 (1973)Google Scholar

Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • H. Galbo
    • 1
  • L. Hummer
    • 2
  • I. B. Petersen
    • 3
  • N. J. Christensen
    • 4
  • N. Bie
    • 1
  1. 1.Institute of Medical Physiology BUniversity of CopenhagenCopenhagen ØDenmark
  2. 2.Department of Nuclear MedicineRigshospitaletCopenhagenDenmark
  3. 3.Department of Clinical ChemistryFinsen HospitaletCopenhagenDenmark
  4. 4.Second Clinic of Internal MedicineKommunehospitaletAarhusDenmark

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