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A portrait of the pancreatic B-Cell

The Minkowski award lecture delivered on July 19, 1973, during the VIIIth congress of the international diabetes Federation, held in Brussels, Belgium

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acinar cells


cell coat


cell membrane or plasma membrane


coated vesicles


cell web




endocytotic vesicle


Golgi complex


gap junction


intercellular space


inner cisternae of the Golgi complex




maturing granule


microvillous process








nuclear pore


outer cisternae of the Golgi complex


rough endoplasmic reticulum


secretory granule


transitional elements of the rough endoplasmic reticulum


tight junction


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Orci, L. A portrait of the pancreatic B-Cell. Diabetologia 10, 163–187 (1974). https://doi.org/10.1007/BF00423031

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Key words

  • Insulin-producing cell
  • insulin biosynthesis
  • insulin release
  • emiocytosis
  • exocytosis
  • endocytosis
  • membrane recycling
  • islet junctional complexes
  • tight junc-tions
  • gap junctions
  • cell coat
  • electron microscopy
  • freeze-etching
  • radioautography
  • cytochemistry