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Diabetologia

, Volume 2, Issue 2, pp 127–129 | Cite as

Plasma β-hydroxybutyric acid response to nicotinic acid-induced plasma free fatty acid decrease in man

  • L. A. Carlson
  • J. Östman
Preliminary Communications
Received:

Summary

Nicotinic acid was in acute studies administered to 4 patients with untreated juvenile diabetes and to 4 obese fasting patients. In all cases the plasma level of FFA decreased. This was soon followed by a decrease in plasma β-hydroxybutyric acid. The effects were less prompt and pronounced in the obese fasting subjects. There were lesser changes in the concentration of blood glucose.

Keywords

Nicotinic Acid Juvenile Diabetes Plasma Free Fatty Acid Acute Study Acid Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Réponse de l'acide β-hydroxybutyrique du plasma à la chute des acides gras libres provoquée par l'acide nicotinique

Résumé

4 malades avec diabète juvénile non-traité et 4 personnes obèses à jeun ont reçu de l'acide nicotinique dans une étude aiguë. Dans tous les cas le taux des acides gras libres du plasma descendait, suivi par une chute de l'acide bêta-hydroxybutyrique dans le plasma. Les effets étaient moins prompts et moins prononcés chez les personnes obèses à jeun. Des modifications moindres du glucose sanguin ont été observées.

Verhalten der Plasma β-hydroxy-Buttersäure nach durch Nikotinsäure ausgelöstem Abfall der freien Fettsäure beim Menschen

Zusammenfassung

4 Patienten mit unbehandeltem, jugendlichen Diabetes und 4 Adipöse im Hungerzustand erhielten im akuten Versuch Nikotinsäure. Bei allen Versuchspersonen trat ein Abfall der freien Fettsäuren im Plasma ein, an den sich ein Absinken des β-hydroxy-buttersäure-Spiegels im Plasma anschloß. Bei den übergewichtigen Personenim Hungerzustand setzten diese Wirkungen langsamer ein und waren schwächer ausgeprägt. Die Blutzuckerspiegel änderten sich in geringerem Ausmaße.

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Copyright information

© Springer-Verlag 1966

Authors and Affiliations

  • L. A. Carlson
    • 1
  • J. Östman
    • 1
  1. 1.King Gustav V Research InstituteStockholm 60Sweden

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