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Relationship between changes of serum cholecystokinin-pancreozymin and serum insulin after different stimuli

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The relationship between changes of serum immuno-reactive cholecystokinin-pancreozymin (CCK-PZ) and serum immuno-reactive insulin has been studied after various stimuli. The oral administration of 5% glucose or magnesium sulphate and the intra-duodenal administration of olive oil were all followed by a rise of serum CCK-PZ. The serum insulin rose after 5% glucose and also showed a small but insignificant rise with olive oil. There was, however, no change of serum insulin after the ingestion of magnesium sulphate suggesting that CCK-PZ in isolation does not stimulate insulin release.


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Based in part on a paper presented to the British Diabetic Association on September 21st 1973.

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Grayburn, J.A., Harvey, R.F., Jennings, R.D. et al. Relationship between changes of serum cholecystokinin-pancreozymin and serum insulin after different stimuli. Diabetologia 11, 35–38 (1975).

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Key words

  • Cholecystokinin-pancreozymin
  • insulin release
  • glucose
  • magnesium sulphate
  • olive oil