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Relationship between changes of serum cholecystokinin-pancreozymin and serum insulin after different stimuli

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Summary

The relationship between changes of serum immuno-reactive cholecystokinin-pancreozymin (CCK-PZ) and serum immuno-reactive insulin has been studied after various stimuli. The oral administration of 5% glucose or magnesium sulphate and the intra-duodenal administration of olive oil were all followed by a rise of serum CCK-PZ. The serum insulin rose after 5% glucose and also showed a small but insignificant rise with olive oil. There was, however, no change of serum insulin after the ingestion of magnesium sulphate suggesting that CCK-PZ in isolation does not stimulate insulin release.

References

  1. 1.

    Bayliss, W. M., Starling, E. H.: Mechanism of pancreatic secretion. J. Physiol. (Lond.) 28, 325–353 (1902)

  2. 2.

    Dale, H.: On the islets Langerhans in the pancreas. Phil. Trans. 197, B 25–46 (1905)

  3. 3.

    McIntyre, N., Holdsworth, C. D., Turner, D. S.: Intestinal factors in the control of insulin secretion. J. clin. Endocr. 25, 1317–1324 (1965)

  4. 4.

    Scow, R. O., Cornfield, J.: Quantitative relations between the oral and intravenous glucose tolerance curves. Amer. J. Physiol. 179, 435–438 (1954)

  5. 5.

    Conard, V., Franckson, R. I., Bastenie, P. A., Kestens, I. C., Kovacs, L.: Etudes critiques du triangle d'hyperglycémie intraveineux chez l'homme normal et determination d'un coefficient dissimulation glucidique. Arch. Int. Pharmacodyn. 93, 277–284 (1953)

  6. 6.

    Elrick, H., Stimmler, C., Hlad, C. J., Jr., Arai, Y.: Plasma insulin response to oral intravenous glucose administration. J. clin. Endocr. 24, 1076–1082 (1964)

  7. 7.

    Schröder, L. E., Raptis, S., Faulbaber, J. D., Pfeiffer, E. F.: Die Wirkung von Pankreozymin auf Blutzucker, immunologisch meßbarem Insulin, freien Fettsäuren und Glycerin beim Menschen. In: Symp. Dtsch. Ges. Endokrinologie, Heidelberg, 7–9 März 1968 S. 170–171 Heidelberg: Springer-Verlag (1969)

  8. 8.

    Dupré, J., Curtis, J. D., Waddell, R. W., Beck, J. C.: Regulation of pancreatic endocrine function by gastrointestinal hormones. Proc. roy. Soc. Med. 8, 815–816 (1968)

  9. 9.

    Fußgänger, R. D., Straub, K., Goberna, R., Jaros, P., Schröder, K. G., Raptis, S., Pfeiffer, E. F.: Primary secretion of insulin and secondary release of glucagon from isolated perfused rat pancreas following stimulation with pancreozymin. Horm. Metab. Res. 1, 224–227 (1969)

  10. 10.

    Hinz, M. N., Katsilambros, N., Schweitzer, B., Raptis, S., Pfeiffer, E. F.: The role of the exocrine pancreas in the stimulation of insulin secretion by intestinal hormones. 1. The effect of pancreozymin, secretin, gastrin-pentapeptide and of glucagon upon insulin secretion of isolated islets of rat pancreas. Diabetologia 7, 1–5 (1971)

  11. 11.

    Unger, R. H., Ketterer, H., Dupré, J., Eisentraut, A.: The effects of secretin, pancreozymin and gastrin on insulin and glucagon secretion in anesthetized dogs. J. clin. Invest. 46, 630–645 (1967)

  12. 12.

    Meade, R. C., Kneubuhler, H. A., Schulte, W. J., Barboriak, J. J.: Stimulation of insulin secretion by pancreozymin. Diabetes 16, 141–144 (1967)

  13. 13.

    Lucke, C., Höffken, B., Mitzkat, H. J., Trautschold, I.: Effect of 2-deoxy-D-glucose and mannoheptulose on the insulin response to pancreozymin in rabbits. Horm. Metab. Res. 6, 21–25 (1974)

  14. 14.

    Mahler, R. J., Weisberg, H.: Failure of endogenous stimulation of secretin and pancreozymin release to influence serum insulin. Lancet 1968 I, 448–451

  15. 15.

    Harvey, R. F., Dowsett, Lynda, Hartog, M., Read, A. E.: Radioimmunoassay of cholecystokinin-pancreozymin. Gut 15, 690–699 (1974)

  16. 16.

    Pennock, C. A., Murphy, D., Sellers, J., Longdon, K. J.: A comparison of auto-analyser methods for the estimation of glucose in blood. Clin. chim. Acta 48, 193–201 (1973)

  17. 17.

    Keane, P. M., Pearson, J., Walker, W. H. C.: Dextran-coated charcoal immunoassay of insulin. Diabetologia 4, 339–344 (1968)

  18. 18.

    Harvey, R. F., Read, A. E.: Saline purgatives act by releasing cholecystokinin. Lancet 1973 II, 185–187.

  19. 19.

    Hedner, P., Persson, G., Ursing, D.: Failure of intravenous cholecystokinin to elicit insulin release in man. Acta Endocr. Suppl. 177, 327 (Abst.) (1973)

  20. 20.

    Rabinowitch, A., Dupré, J.: Insulinotropic and glucagonotropic activities in crude preparations of cholecystokinin-pancreozymin. Clin. Res. 20, 945 (1972)

  21. 21.

    Rabinowitch, A., Dupré, J.: Effects of the gastric inhibitory polypeptide present in impure pancreozymin-cholecystokinin on plasma insulin and glucagon in the rat. Endocrinology 94, 1139–1144 (1974)

  22. 22.

    Ivy, A. C.: The physiology of the gallbladder. Physiol. Rev. 14, 1–102 (1934)

  23. 23.

    Wang, C. C., Grossman, M. I.: Physiological determination of release of secretin and pancreozymin from intestine of dogs with transplanted pancreas. Amer. J. Physiol. 164, 527–545 (1951)

  24. 24.

    Harper, A. A., Vass, C. C. N.: The control of the external secretion of the pancreas in cats. J. Physiol. (Lond.) 99, 415–435 (1941)

  25. 25.

    Bergström, K., Lundh, G.: Determination of trypsin in duodenal fluid as a test of pancreatic function. A methodological note. Scand. J. Gastroent. 5, 533–536 (1970)

  26. 26.

    Lurie, B., Novis, B. H., Brom, B., Bank, S., Marks, I. N.: Pancreatic exocrine responses to test meals of varying composition in man. Amer. J. dig. Dis. 18, 847–850 (1973)

  27. 27.

    Pi Sunyer, X. F., Hashim, S. A., Van Itallie, T. B.: Insulin and ketone responses to ingestion of medium and longchain triglycerides in man. Diabetes 18, 96–100 (1969)

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Based in part on a paper presented to the British Diabetic Association on September 21st 1973.

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Grayburn, J.A., Harvey, R.F., Jennings, R.D. et al. Relationship between changes of serum cholecystokinin-pancreozymin and serum insulin after different stimuli. Diabetologia 11, 35–38 (1975). https://doi.org/10.1007/BF00422815

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Key words

  • Cholecystokinin-pancreozymin
  • insulin release
  • glucose
  • magnesium sulphate
  • olive oil