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Mechanisms of glucose stimulated insulin secretion in health and in diabetes: Some re-evaluations and proposals

The Minkowski Award Lecture delivered on September 12, 1974, before the European Association for the Study of Diabetes at Jerusalem, Israel


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    Cerasi, E., Hallberg, D., Luft, R.: Simultaneous determination of insulin in brachial and portal veins during glucose infusion in normal and prediabetic subjects. Horm. metab. Res. 2, 303–304 (1970)

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    Grill, V., Cerasi, E.: Stimulation by D-glucose of cyclic 3′,5′-adenosine monophosphate accumulation and insulin release in isolated pancreatic islets of the rat. J. biol. Chem. 249, 4196–4201 (1974)

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    Cerasi, E.: Feed-back inhibition of insulin secretion in subjects with high and low insulin response to glucose. To be published

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    Efendic, S., Cerasi, E., Luft, R.: Quantitative study on the potentiating effect of arginine on glucose-induced insulin response in healthy, prediabetic, and diabetic subjects. Diabetes 23, 161–171 (1974)

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    Cerasi, E.: Potentiation of insulin release by glucose in man. II. Role of the insulin response, and potentiation of stimuli other than glucose. Acta endocr. (Kbh.), in press (1975)

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    Gutzeit, A., Rabinovitch, A., Karakash, C., Stauffacher, W., Renold, A. E., Cerasi, E.: Evidence for decreased sensitivity to glucose of isolated islets from spiny mice (Acomys cahirinus). Diabetologia 10, Suppl. 661–665 (1974)

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    Cerasi, E., Luft, R.: The effect of an adenosine 3′,5′ monophosphate diesterase inhibitor (Aminophylline) on the insulin response to glucose infusion in prediabetic and diabetic subjects. Horm. metab. Res. 1, 162–168 (1969)

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    Cerasi, E.: Potentiation of insulin release by glucose in man. III. Normal recognition of glucose as a potentiator in subjects with low insulin response and in mild diabetics. Acta endocr. (Kbh.), in press (1975)

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Cerasi, E. Mechanisms of glucose stimulated insulin secretion in health and in diabetes: Some re-evaluations and proposals. Diabetologia 11, 1–13 (1975).

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Key words

  • Glucose-induced insulin secretion
  • initiation of release
  • cyclic AMP
  • cholera toxin
  • phosphodiesterase inhibition
  • glucoreceptor
  • glucose utilization
  • calcium ions
  • potentiation of release
  • adrenaline
  • glucagon
  • diabetes
  • prediabetes
  • Acomys
  • isolated islets
  • perifusion
  • perfused pancreas