Role of calf thymus DNA-Topoisomerase I phosphorylation on relaxation activity expression and on DNA-protein interaction
- the native protein is partially phosphorylated,
- the phosphorylation involvement is essential for the activity expression and also for DNA-protein interaction,
- changes in the degree of phosphorylation might be involved in the regulation of DNA processing; that evokes some properties of chromatinic peptide models, which bind DNA only when phosphorylated and leads to the assumption that they represent the minimum functional substrate for N II protein kinase.
Key wordsDNA-protein interaction phosphorylation/dephosphorylation Topoisomerase I
poly acrylamide gel electrophoresis
sodium dodecyl sulfate
- Topo I
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