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Psychopharmacologia

, Volume 26, Issue 3, pp 307–312 | Cite as

Inhibition of ethanol-induced excitation in mice and rats by α-methyl-p-tyrosine

  • A. Carlsson
  • J. Engel
  • T. H. Svensson
Preliminary Reports Animal Studies

Abstract

Small doses of ethanol (1 or 2 g/kg 20% w/v) caused increased motor activity in rats and mice as measured by an Animex activity meter. This effect was prevented by pretreatment with the tyrosine hydroxylase inhibitor α-methyl-p-tyrosine methyl ester hydrochloride, in doses of 40 or 200 mg/kg which per se caused no significant depression of motor activity. The data implicate a role for newly synthesized catecholamines in ethanol-induced motor stimulation.

Key words

Ethanol Motor Activity Catecholamine Synthesis Inhibition 

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • A. Carlsson
    • 1
  • J. Engel
    • 1
  • T. H. Svensson
    • 1
  1. 1.Department of PharmacologyUniversity of GöteborgSweden

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