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Psychopharmacologia

, Volume 31, Issue 3, pp 265–270 | Cite as

Gas chromatographic-mass spectrometric isotope dilution determination of N,N-dimethyltryptamine concentrations in normals and psychiatric patients

  • R. J. Wyatt
  • L. R. Mandel
  • H. S. Ahn
  • R. W. Walker
  • W. J. A. Vanden Heuvel
Human Pharmacology

Abstract

A gas chromatographic-mass spectrometric determination of the plasma N,N-dimethyltryptamine concentration from normals and psychiatric patients revealed that within the limit of sensitivity of the assay (0.5–1.8 ng/ml of plasma), there was no difference amongst normals, patients with psychotic depression, acute and chronic schizophrenia.

Key words

Dimethyltryptamine Hallucinogens Schizophrenia 

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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • R. J. Wyatt
    • 1
  • L. R. Mandel
    • 2
  • H. S. Ahn
    • 2
  • R. W. Walker
    • 2
  • W. J. A. Vanden Heuvel
    • 2
  1. 1.Laboratory of Clinical Psychopharmacology, Division of Special Mental Health Research, IRP, National Institute of Mental HealthSaint Elizabeths HospitalWashington, D.C.
  2. 2.Merck Sharp & Dohme Research LaboratoriesRahway

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