, Volume 73, Issue 3, pp 286–291 | Cite as

Similarity of the discriminative stimulus effects of ketamine, cyclazocine, and dextrorphan in the pigeon

  • Seymore Herling
  • Edward H. CoaleJr.
  • David W. Hein
  • Gail Winger
  • James H. Woods
Original Investigations


Separate groups of pigeons were trained to discriminate the IM injection of ketamine, cyclazocine, or dextrorphan from saline. Each of the training drugs and phencyclidine produced dose-related, drug-appropriate responding in each group of birds. In contrast, ethylketazocine and nalorphine generally produced responding appropriate for saline. These results indicate that common elements of discriminable effects exist among ketamine, cyclazocine, and dextrorphan, structurally dissimilar compounds that are generally considered to belong to distinct pharmacological classes.

Key words

Phencyclidine Drug discrimination Ketamine Pigeons Dextrorphan Ethylketazocine Cyclazocine Nalorphine 


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  1. Barry H III (1974) Classification of drugs according to their discriminable effects in rats. Fed Proc 33:1814–1824Google Scholar
  2. Colpaert FC (1978) Discriminative stimulus properties of narcotic analgesic drugs. Pharmacol Biochem Behav 9:863–887Google Scholar
  3. Colpaert FC, Desmedt LKC, Janssen PAJ (1976) Discriminative stimulus properties of benzodiazepines, barbiturates, and pharmacologically related drugs; relation to some intrinsic and anticonvulsant effects. Eur J Pharmacol 37:133–123Google Scholar
  4. Domino EF (1964) Neurobiology of phencyclidine (Sernyl), a drug with an unusual spectrum of pharmacological activity. Int Rev Neurobiol 6:303–347Google Scholar
  5. Domino EF, Chodoff P, Corssen GL (1965) Pharmacologic effects of CI-581, a new dissociative anesthetic in man. Clin Pharmacol Ther 6:279–291Google Scholar
  6. Gilbert PE, Martin WR (1976) The effects of morphine- and nalorphine-like drugs in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog. J Pharmacol Exp Ther 198:66–82Google Scholar
  7. Gilbert PE, Martin WR (1977) Antagonism of the effects of pentobarbital in the chronic spinal dog by naltrexone. Life Sci 20:1401–1406Google Scholar
  8. Haertzen CA (1974) Subjective effects of narcotic antagonists. In: Braude MC, Harris LS, May EL, Smith JP, Villarreal JE (eds) Narcotic antagonists, Raven Press, New York, pp 383–398Google Scholar
  9. Herling S, Coale EH Jr, Valentino RJ, Hein DW, Woods JH (1980) Narcotic discrimination in pigeons. J Pharmacol Exp Ther 214:139–146Google Scholar
  10. Holtzman SG (1980) Phencyclidine-like discriminative effects of opioids in the rat. J Pharmacol Exp Ther 214:614–619Google Scholar
  11. Holtzman SG, Shannon HE, Schaefer GJ (1977) Discriminative properties of narcotic antagonists. In: Lal H (ed) Discriminative stimulus properties of drugs, Plenum Press, New York, pp 47–72Google Scholar
  12. Isbell H, Fraser HF (1953) Actions and addiction liabilities of Dromoran derivatives in man. J Pharmacol Exp Ther 107:524–530Google Scholar
  13. Jasinski DR, Martin WR, Mansky PA Progess report on the assessment of the antagonists nalbuphine and GPA-2087 for abuse potential and studies of the effects of dextromethorphan in man. Reported to the 33rd Meeting, Committee on Problems of Drug Dependence, Toronto, Canada 1971. National Academy of Sciences/National Research Council, pp 143–178Google Scholar
  14. Jasinski DR, Shannon HE, Cone EJ, Vaupel DB, Risner ME, McQuinn RL, Su TP, Pickworth WB (1981) Interdisciplinary studies on phencyclidine. In: Domino EF (ed) PCP (Phencyclidine): Historical and current perspectives, NPP Books, Ann Arbor (in press)Google Scholar
  15. Keats AS, Telford J (1964) Natcotic antagonists as analgesics: Clinical aspects. In: Gould RF (ed) Molecular modification in drug design (Advances in Chemistry, Series 45), American Chemical Society, Washington, pp 170–176Google Scholar
  16. Martin WR, Eades CG, Thompson JA, Huppler RE, Gilbert PE (1976) The effects of morphine- and nalorphine-like drugs in the non-dependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther 197:517–532Google Scholar
  17. Martin WR, Gilbert PE, Thompson JA, Jessee CA (1978) Use of the chronic spinal dog for the assessment of the abuse potentiality and utility of narcotic analgesics and narcotic antagonists. Drug Alcohol Depend 3:23–34Google Scholar
  18. Overton DA (1975) A comparison of the discriminable CNS effects of ketamine, phencyclidine and pentobarbital. Arch Int Pharmacodyn 215:180–189Google Scholar
  19. Overton DA, Batta SK (1979) Investigation of narcotics and antitussives using drug discrimination techniques. J Pharmacol Exp Ther 211:401–408Google Scholar
  20. Poling AD, White FJ, Appel JB (1979) Discriminative stimulus properties of phencyclidine. Neuropharmacology 18:459–463Google Scholar
  21. Shannon HE (1979) Evalution of phencyclidine analogs on the basis of their discriminative stimulus properties in the rat. Fed Proc 38:435Google Scholar
  22. Shannon HE, Holtzman SG (1976) Evaluation of the discriminative effects of morphine in the rat. J Pharmacol Exp Ther 198:54–65Google Scholar
  23. Teal JJ, Holtzman SG (1980) Discriminative stimulus effects of cyclazocine in the rat. J Pharmacol Exp Ther 212:368–376Google Scholar
  24. Vaupel DB, Jasinski DR (1979) Acute single dose effects of phencyclidine (PCP) in the dog. Fed Proc 38:435Google Scholar
  25. Vaupel DB, Nozaki M, Martin WR, Bright LD (1978) Single dose and cross tolerance studies of β-phenethylamine, d-amphetamine and LSD in the chronic spinal dog. Eur J Pharmacol 48:431–437Google Scholar
  26. Weissman A (1978) Generalization of the discriminative stimulus properties of Δ9-tetrahydocannabinol to cannabinoids of therapeutic potential. In: Colpaert FC, Rosecrans JA (eds) Stimulus properties of drugs: Ten years of progress, Elsevier/North Holland Biomedical Press, Amsterdam, pp 99–122Google Scholar
  27. Wiley JT, Holtzman SG (1978) Discriminative effects of dextromethorphan and dextrorphan in the squirrel monkey. Fed Proc 37:322Google Scholar
  28. Woods JH, Herling S, Valentino RJ, Hein DW, Coale EH Jr. (1980) Narcotic drug discriminations by rhesus monkeys and pigeons. In: Harris LS (ed) Problems of drug dependence, 1979: Proceedings of the 41st annual scientific meeting, The Committee on Problems of Drug Dependence (NIDA Research Monograph 27) U. S. Government Printing Office, Washington, pp 128–134Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Seymore Herling
    • 1
  • Edward H. CoaleJr.
    • 1
  • David W. Hein
    • 1
  • Gail Winger
    • 1
  • James H. Woods
    • 1
  1. 1.Departments of Pharmacology and PsychologyUniversity of MichiganAnn ArborUSA

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