Psychopharmacology

, Volume 73, Issue 3, pp 286–291 | Cite as

Similarity of the discriminative stimulus effects of ketamine, cyclazocine, and dextrorphan in the pigeon

  • Seymore Herling
  • Edward H. CoaleJr.
  • David W. Hein
  • Gail Winger
  • James H. Woods
Original Investigations

Abstract

Separate groups of pigeons were trained to discriminate the IM injection of ketamine, cyclazocine, or dextrorphan from saline. Each of the training drugs and phencyclidine produced dose-related, drug-appropriate responding in each group of birds. In contrast, ethylketazocine and nalorphine generally produced responding appropriate for saline. These results indicate that common elements of discriminable effects exist among ketamine, cyclazocine, and dextrorphan, structurally dissimilar compounds that are generally considered to belong to distinct pharmacological classes.

Key words

Phencyclidine Drug discrimination Ketamine Pigeons Dextrorphan Ethylketazocine Cyclazocine Nalorphine 

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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Seymore Herling
    • 1
  • Edward H. CoaleJr.
    • 1
  • David W. Hein
    • 1
  • Gail Winger
    • 1
  • James H. Woods
    • 1
  1. 1.Departments of Pharmacology and PsychologyUniversity of MichiganAnn ArborUSA

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