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Immuno-fluorescent reactivity to anti-somatostatin in the gastro-intestinal mucosa of the dog

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Evidence is presented that somatostatin-containing cells are present in the gastro-intestinal tract of the dog. Thus immuno-fluorescent cells were detected by the use of antiserum to cyclic somatostatin. These cells were mainly encountered in the antral mucosa and in the neighbourhood of gastrin-producing cells. No cross reaction was observed between gastrin and somatostatin. It is suggested that locally produced somatostatin controls gastrin secretion, and, more generally, that somatostatin-containing cells, multifocally distributed, modulates secretion of a large number of glands.


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Rufener, C., Dubois, M.P., Malaisse-Lagae, F. et al. Immuno-fluorescent reactivity to anti-somatostatin in the gastro-intestinal mucosa of the dog. Diabetologia 11, 321–324 (1975). https://doi.org/10.1007/BF00422398

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Key words

  • Immuno-fluorescence
  • gastro-intestinal tract
  • somatostatin
  • gastrin