Diabetologia

, Volume 11, Issue 3, pp 221–224 | Cite as

Increased kidney size and glomerular filtration rate in untreated juvenile diabetes: Normalization by insulin-treatment

  • C. E. Mogensen
  • M. J. F. Andersen
Originals

Summary

Glomerular filtration rate (GFR), renal plasma flow (RPF) and roentgenographic kidney size were measured in six newly diagnosed male diabetics with a mean age of 25 years. Glomerular filtration rate was elevated before treatment to the same extent as found previously. A significant fall in both kidney size and glomerular filtration rate was found after treatment with insulin for 3 months. These results support further the concept that there is a basal connection between enlarged kidneys and the elevated GFR of early diabetes.

Key words

Glomerular filtration rate renal plasma flow kidney size insulin treatment diabetes mellitus 

References

  1. 1.
    Cambier, P.: Application de la théorie de Rehberg a l'etude clinique des affections rénales et du diabete. Ann. med. Nancy 35, 273–299 (1934)Google Scholar
  2. 2.
    Corvilain, J., Abramow, M.: Some effects of human growth hormone on renal hemodynamics and on tubular phosphate transport in man. J. clin. Invest. 41, 1230–1235 (1962)Google Scholar
  3. 3.
    Ditzel, J., Schwartz, M.: Abnormally increased glomerular filtration rate in short-term insulin-treated diabetic subjects. Diabetes 16, 264–267 (1967)Google Scholar
  4. 4.
    Ditzel, J., Junker, K.: Abnormal glomerular filtration rate, renal plasma flow, and renal protein excretion in recent and short-term diabetics. Brit. med. J. 1972 II, 13–19Google Scholar
  5. 5.
    Gershberg, H., Heinemann, H. O., Stumf, H. H.: Renal function studies and autopsy report in a patient with gigantism and acromegaly. J. clin. Endocr. 17, 377–385 (1957)Google Scholar
  6. 6.
    Hansen, A. P.: Abnormal serum growth hormone response to exercise in juvenile diabetics. J. clin. Invest. 49, 1367–1478 (1970)Google Scholar
  7. 7.
    Kimmelstiel, P.: Diabetic nephropathy in: structural basis of renal disease, (ed E. Lovell Becker, Hoeber Medical Division) New York 1968Google Scholar
  8. 8.
    Möell, H.: Kidney size and its deviation from normal in acute renal failure. Acta radiol. (Stockh.) Suppl. 206 (1961)Google Scholar
  9. 9.
    Mogensen, C. E.: Kidney function and glomerular permeability to macromolecules in early juvenile diabetes. Scand. J. clin. Lab. Invest. 28, 79–90 (1971)Google Scholar
  10. 10.
    Mogensen, C. E.: Glomerular filtration rate and renal plasma flow in short-term and long-term juvenile diabetes. Scand. J. clin. Lab. Invest. 28, 91–100 (1971)Google Scholar
  11. 11.
    Mogensen, C. E.: Maximum tubular reabsorption capacity for glucose and renal hemodynamics during rapid hypertonic glucose infusion in normal and diabetic subjects. Scand. J. clin. Lab. Invest. 28, 101–109 (1971)Google Scholar
  12. 12.
    Mogensen, C. E.: Glomerular filtration rate and renal plasma flow in normal and diabetic man during elevation of blood sugar levels. Scand. J. clin. Lab. Invest. 28, 183–193 (1971)Google Scholar
  13. 13.
    Mogensen, C. E.: Kidney function and glomerular permeability to macromolecules in juvenile diabetes. Dan. med. Bull. 19, suppl. 3 (1972)Google Scholar
  14. 14.
    Mogensen, C. E.: Elevated glomerular filtration rate in insulin treated short-term diabetes. Acta med. scand. 194, 559–561 (1973)Google Scholar
  15. 15.
    Mogensen, C. E., Andersen, M. J. F.: Increased kidney size and glomerular filtration rate in early juvenile diabetes. Diabetes 22, 706–712 (1973)Google Scholar
  16. 16.
    Østerby, R., Gundersen, H. J. G.: Glomerular size and morphology in diabetes mellitus. I. Early Abnormalities. Diabetologia 11, 225–229 (1975)Google Scholar
  17. 17.
    Stalder, G., Schmid, R., Wolff, M. V.: Funktionelle Mikroangiopathie der Nieren beim behandelten Diabetes mellitus im Kindesalter. Dtsch. med. Wschr. 85, 346–350 (1960)Google Scholar

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • C. E. Mogensen
    • 1
  • M. J. F. Andersen
    • 1
  1. 1.Second Clinic of Internal Medicine and the Roentgen Diagnostic DepartmentUniversity of AarhusKommunehospitaletDenmark

Personalised recommendations