Influence of morphine on lateral hypothalamic self-stimulation in the rat
Animal Studies
Received:
- 48 Downloads
- 110 Citations
Abstract
Morphine (5, 10, and 20 mg/kg, subcutaneously) both suppressed and elevated lateral hypothalamic self-stimulation response output. The duration of the depressant effect and the temporal appearance of the excitatory influence were dose dependent. With repeated daily injection tolerance developed to the suppressive effect while the facilitatory effect appeared ealier and tended to be enhanced. Thus the facilitatory action is not due simply to a rebound phenomenon. Finally, no correlation between the effects of morphine on self-stimulation behavior and on wheel-running activity was observed.
Key words
Self-Stimulation Lateral Hypothalamus Morphine Drug TolerancePreview
Unable to display preview. Download preview PDF.
References
- Adams, W. J., Lorens, S. A., Mitchell, C. L.: Morphine enhances lateral hypothalamic self-stimulation in the rat. Proc. Soc. exp. Biol. (N. Y.) 140, 770–771 (1972)Google Scholar
- Bauxbaum, D. M., Yarbrough, G. G., Carter, M. E.: The anterior thalamus as a site of morphine action. Bull. Prob. Drug Depend. 1, 515–531 (1971)Google Scholar
- DeGroot, J.: The rat forebrain in steteotaxic coordinates. Trans. roy. Neth. Acad. Sci. 52, 1–40 (1959)Google Scholar
- Eidelberg, E., Schwartz, A. S.: Possible mechanism of action of morphine on brain. Nature (Lond.) 225, 1152–1153 (1970)Google Scholar
- Lorens, S. A.: Effect of lesions in the central nervous system on lateral hypothalamic self-stimulation in the rat. J. comp. physiol. Psychol. 62, 256–262 (1966)Google Scholar
- Olds, J., Travis, R. P.: Effects of chlorpromazine, meprobamate, pentobarbital and morphine on self-stimulation. J. Pharmacol. exp. Ther. 128, 397–404 (1960)Google Scholar
Copyright information
© Springer-Verlag 1973