Psychopharmacologia

, Volume 26, Issue 2, pp 93–114 | Cite as

Addiction to secobarbital and chlordiazepoxide in the rhesus monkey by means of a self-infusion preference procedure

  • Jack D. Findley
  • W. W. Robinson
  • L. Peregrino
Original Investigations Animal Studies

Abstract

Monkeys were exposed to a 24 h continuous experimental procedure which provided a periodic forced choice between the self-infusion of secobarbital versus saline. Preference for secobarbital over saline was readily obtained using choice trials programmed approximately every 2 h at a dose of 9 mg/kg of secobarbital per infusion. Preference for self-infusion of chlordiazepoxide over saline was obtained using choice trials every 3 h, and a dose on the order of 1 mg/kg per infusion. In a subsequent experiment, two of the animals addicted to chlordiazepoxide were given a choice every 3 h between an infusion of chlordiazepoxide or secobarbital. Following a period of intake of both drugs, a gradual shift in preference from chlordiazepoxide to secobarbital was observed over a period of some 60 days. In general, this preference procedure provides a flexible technique with several dependent measures for single or multiple drug addiction studies.

Key words

Self-Infusion Primates Secobarbital Chlordiazepoxide Choice Procedure Preference Multiple Addiction 

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • Jack D. Findley
    • 1
  • W. W. Robinson
    • 1
  • L. Peregrino
    • 1
  1. 1.Division of Behavioral Biology, Department of Psychiatry and Behavioral SciencesThe Johns Hopkins University School of MedicineBaltimore

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