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Addiction to secobarbital and chlordiazepoxide in the rhesus monkey by means of a self-infusion preference procedure

Abstract

Monkeys were exposed to a 24 h continuous experimental procedure which provided a periodic forced choice between the self-infusion of secobarbital versus saline. Preference for secobarbital over saline was readily obtained using choice trials programmed approximately every 2 h at a dose of 9 mg/kg of secobarbital per infusion. Preference for self-infusion of chlordiazepoxide over saline was obtained using choice trials every 3 h, and a dose on the order of 1 mg/kg per infusion. In a subsequent experiment, two of the animals addicted to chlordiazepoxide were given a choice every 3 h between an infusion of chlordiazepoxide or secobarbital. Following a period of intake of both drugs, a gradual shift in preference from chlordiazepoxide to secobarbital was observed over a period of some 60 days. In general, this preference procedure provides a flexible technique with several dependent measures for single or multiple drug addiction studies.

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References

  1. Bremner, F. J., Cobb, H. W., Hahn, W. C.: The effects of chlordiazepoxide on the behavior of rats in a conflict situation. Psychopharmacologia (Berl.) 17, 275–282 (1970).

  2. Davis, J. P., Miller, N. E.: Fear and pain: Their effect on self-injection of amobarbital sodium by rats. Science 141, 1287–1288 (1963).

  3. Deneau, G. A.: Drug self-administration by monkeys. In: H. Steinberg (Ed.): Scientific Basis of Drug Dependence. London: J. H. Churchill 1968.

  4. —, Yanagita, T., Seevers, M. H.: Psychic dependence studies of self-administration techniques in Rhesus monkeys. Comm. Drug Addiction and Narcotics, NRC-NAS, Houston, Texas (1965).

  5. Findley, J. D., Robinson, W. W.: Aversive preference as a function of fixed-ratio requirements. East. Psychol. Ass. (N. Y.) (1971).

  6. — —, Gilliam, W.: A restraint system for chronic study of the baboon. J. exp. Anal. Behav. 15, 69–71 (1971).

  7. — — —, Brady, J. V.: Continuous cardiovascular monitoring in the baboon during long-term behavioral performances. Commun. Behav. Biol. 6, 45–58 (1971).

  8. Geller, E., Kulak, S.: Effects of CDP on punished discrimination. Psychopharmacologia (Berl.) 3, 373–385 (1962).

  9. Goldberg, S. R., Hoffmeister, F., Schlichting, V., Wuttke, W.: A comparison of pentobarbital and cocaine self-administration in rhesus monkeys: Effects of dose and fixed-ratio parameters. J. Pharmacol. exp. Ther. 179, 277–283 (1971).

  10. Perez-Cruet, J., Plumlee, L., Newton, J. E. O.: Chronic basal blood pressure in unanesthetized dogs using the ring-catheter technique. Proc. Symp. Biomed. Engr. 1, 383–386 (1964).

  11. Schuster, C. R., Thompson, T.: A technique for studying self-administration of opiates in Rhesus monkeys. Comm. Drug Addication and Narcotics, NRC-NAS, Ann. Arbor, Mich. (1963).

  12. — —: Self-administration of and behavioral dependence on drugs. Ann. Rev. Pharmacol. 9, 483–502 (1969).

  13. Weeks, J. R.: Fed. Proc. 20 (1961).

  14. Werdegar, D., Johnson, D. G., Mason, J. W.: A technique for continuous measurements of arterial blood pressure in unanesthetized monkeys. J. appl. Physiol. 19, 519–521 (1964).

  15. Yanagita, T., Deneau, G. A., Seevers, M. H.: Methods for studying psychogenic dependence to opiates in the monkey. Comm. Drug Addiction and Narcotics, NRC-NAS, Ann Arbor, Mich. (1963).

  16. —, Takahashi, S.: Development of tolerance to and physical dependence on barbiturates in Rhesus monkeys. J. Pharmacol. exp. Ther. 172, 163–167 (1970).

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Supported in part by a contract from the Department of Justice, Bureau of Narcotics and Dangerous Drugs, J 69 15.

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Findley, J.D., Robinson, W.W. & Peregrino, L. Addiction to secobarbital and chlordiazepoxide in the rhesus monkey by means of a self-infusion preference procedure. Psychopharmacologia 26, 93–114 (1972). https://doi.org/10.1007/BF00422097

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Key words

  • Self-Infusion
  • Primates
  • Secobarbital
  • Chlordiazepoxide
  • Choice Procedure
  • Preference
  • Multiple Addiction