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2,3-diphosphoglycerate during exercise

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The effect of physical exercise on erythrocyte 2,3-diphosphoglycerate (2,3-DPG) content was studied in eight trained speed canoeists aged 15–25 years. One-stage 4-min load on a paddling ergometer corresponding to a 1 km race was observed. During the test, the following cardiorespiratory parameters were recorded: \(\dot V,{\text{ }}\dot V\operatorname{O} _2 ,{\text{ }}\dot V\operatorname{O} _2 /kg,{\text{ }}\operatorname{HR} ,{\text{ }}\dot V\operatorname{O} _2 /\operatorname{HR} , R\). Blood lactate level and haematocrit were also determined. The average resting values of 2,3-DPG and haematocrit were statistically significant increased.

After 6 month intense training there was a significant increase in 2,3-DPG, and the other parameters were also increased.

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\(\dot V\) :

pulmonary ventilation

\(\dot V\operatorname{O} _2 \) :

oxygen uptake

\(\dot V\operatorname{O} _2 /kg\) :

oxygen uptake per one kg of body weight


heart rate

\(\dot V\operatorname{O} _2 /\operatorname{HR} \) :

pulse oxygen


respiratory quotient




arithmetical mean


standard deviation

t :

value of t-test for paired comparisons


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Correspondence to Dr. J. Böswart.

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Böswart, J., Kuta, I., Lisý, Z. et al. 2,3-diphosphoglycerate during exercise. Europ. J. Appl. Physiol. 43, 193–199 (1980). https://doi.org/10.1007/BF00421832

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Key words

  • 2,3-Diphosphoglycerate
  • Exercise