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Psychopharmacologia

, Volume 36, Issue 3, pp 243–253 | Cite as

Morphine and δ9-tetrahydrocannabinol: Tolerance to the stimulus effects

  • Ira D. Hirschhorn
  • John A. Rosecrans
Animal Studies

Abstract

Morphine and saline served as discriminative Stimuli for one group of rats in a 2-lever discrimination task. δ9-THC and vehicle were discriminative stimuli for a second group. Depression of one lever resulted in reinforcement following the administration of morphine or δ9-THC and the opposite lever was reinforced after vehicle. A high degree of discriminated responding occurred with both drugs. During daily supplemental injections of morphine or δ9-THC up to several times the training dose for a period of 2 months, subjects still discriminated morphine or δ9-THC from vehicle. However, the degree of discrimination was reduced indicating a limited tolerance to either drug. Naloxone precipitated narcoticlike withdrawal symptoms in rats chronically treated with either morphine or δ9-THC, indicating that there is an interaction between chronic administration of δ9-THC and the narcotic antagonist, naloxone.

Key words

Morphine δ9-Tetrahydrocannabinol (δ9-THC) Tolerance Physical Dependence Withdrawal Naloxone Discriminative Stimulus 

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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Ira D. Hirschhorn
    • 1
  • John A. Rosecrans
    • 1
  1. 1.Department of PharmacologyMedical College of VirginiaRichmond

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