Advertisement

Psychopharmacologia

, Volume 30, Issue 2, pp 95–102 | Cite as

The effects of benzodiazepines on aggression: Reduced or increased?

  • Alberto DiMascio
Original Investigations Human Pharmacology

Abstract

The effects of various benzodiazepines on animal models of aggression are presented. The differences in response noted after single dose or after chronic drug administrations are stressed. The implications for predicting responses to these drugs in humans are discussed.

Key words

Benzodiazepines Aggression 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bauen, A., Possanza, G. J.: The mink as a psychopharmacological model. Arch. int. Pharmacodyn. 186, 133–136 (1970).Google Scholar
  2. Boissier, J. R., Simon, P., Aron, C.: A new method for rapid screening of minor tranquilizers in mice. Europ. J. Pharmacol. 4, 145–151 (1968).Google Scholar
  3. Boyle, D., Tobin, J.: Pharmaceutical management of behavior disorders. J. med. Soc. N. J. 58, 427–429 (1961).Google Scholar
  4. Brady, J. V., Nauta, W. J. H.: Subcortical mechanisms in emotional behavior; affective changes following septal forebrain lesion in the albino rat. J. Comp. physiol. Psychol. 46, 339–346 (1953).Google Scholar
  5. Christmas, A. J., Maxwell, D. R.: A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats. Neuropharmacology 9, 17–29 (1970).Google Scholar
  6. Cole, H. F., Wolf. H. H.: Laboratory evaluation of aggressive behavior of the grasshopper mouse (Onychomys). J. Pharm. Sci. 59, 969–971 (1970).Google Scholar
  7. Dimascio, A., Shader, R. I., Giller, D. R.: Behavioral toxicity: Part III: perceptualcognitive functions and Part IV: Emotional (mood) states, in Psychotropic Drug Side Effects. R. I. Shader and A. Dimascio, eds., pp. 132–141. Baltimore: Williams & Wilkins 1970.Google Scholar
  8. Dimascio, A., Shader, R. I., Harmatz, J. S.: Psychotropic drugs and induced hostility. Psychosomatics 10, 46–47 (1969).Google Scholar
  9. Feldman, P. E.: An analysis of the efficacy of diazepam. J. Neuropsychiat. (Suppl.) 3, S62-S67 (1962).Google Scholar
  10. Fox, K. A., Snyder, R. L.: Effect of sustained low doses of diazepam on aggression and mortality in grouped male mice. J. comp. physiol. Psychol. 69, 663–666 (1969).Google Scholar
  11. Fox, K. A., Tockosh, J. R., Wolcox, A. H.: Increased aggression among group male mice fed chlordiazepoxide. Europ. J. Pharmacol. 11, 119–121 (1970).Google Scholar
  12. Fox, K. A.: Personal Communication, October 1971.Google Scholar
  13. Fox, K. A., Webster, J. C., Guerriero, F. J.: Increased aggression among grouped male mice fed nitrazepam and flurazepam. Europ. J. Pharmacol. (in press).Google Scholar
  14. Gardos, G., Dimascio, A., Salzman, C., Shader, R. I.: Differential actions of chlordiazepoxide and oxazepam on hostility. Arch. gen. Psychiat. 18, 757–760 (1968).Google Scholar
  15. Gleser, G. C., Gottschalk, L. A., Fox, R., Lippert, W.: Immediate changes in affect with chlordiazepoxide. Arch. gen. Psychiat. 13, 291–295 (1965).Google Scholar
  16. Guaitani, A., Marcucci, F., Garanttini, S.: Increased aggression and toxicity in grouped male mice treated with tranquilizing benzodiazepines. Psychopharmacologia (Berl.) 19, 241–245 (1971).Google Scholar
  17. Heise, G. A., Boff, E.: Taming action of chlordiazepoxide. Fed. Proc. 20, 393 (1961).Google Scholar
  18. Heuschele, W. P.: Chlordiazepoxide for calming zoo animals. J. Amer. vet. med. Ass. 139, 996 (1961).Google Scholar
  19. Hoffmeister, F., Wuttke, W.: On the actions of psychotropic drugs on the attack- and aggressive-defensive behaviour of mice and cats, in Aggressive Behavior. S. Garratini and B. Sigg. eds., pp. 273–280. New York: Wiley 1969.Google Scholar
  20. Horowitz, Z. P., Furgiuele, A. R., Brannick, L. J., Burke, J. C., Craver, B. N.: A new chemical structure with specific depressant effects on the amygdala and on the hyperirritability of the “septal rat” Nature (Lond.) 200, 269 (1963).Google Scholar
  21. Kalina, R. K.: Diazepam: its role in a prison setting. Dis. nerv. Syst. 25, 101 (1964).Google Scholar
  22. Kelley, J. W., Gisvold, D. I.: The use of MMPI in the evaluation of Librium. Colo. G. P. 2, 3–8 (1960).Google Scholar
  23. Kostowski, W.: A note on the effects of some psychotropic drugs on the aggressive behaviour in the ant. Formica rufa. J. Pharm. Pharmacol. 18, 747–749 (1966).Google Scholar
  24. Langfeldt, T., Ursin, H.: Differential action of diazepam on flight and defense behavior in the cat. Psychopharmacologia (Berl.) 19, 61–66 (1971).Google Scholar
  25. Mercier, J., Dessaigne, S.: Influence exercée par quelques drogues psycholeptiques sur le comportement du scorpion (Androctonus australis Hector). C. R. Soc. Biol. (Paris) 164, 341–344 (1970).Google Scholar
  26. Morpurgo, C.: Aggressive behavior induced by large doses of 2-(2,6-dichlorophenyl-amino)-2-imindazoline hydrochloride (ST 155) in mice. Europ. J. Pharmacol. 3, 373–377 (1968).Google Scholar
  27. Podobnikar, I. G.: Implementation of psychotherapy in Librium in a pioneering rural-industrial psychiatric practice. Psychosomatics 12, 205–209 (1971).Google Scholar
  28. Podvalova, I., Dlabac, A., Votava, Z.: Mesorgydine-induced aggressive behavior in rats. Intern. Congr. Pharmacol. (Pamphlet) 4th, Basle, pp. 297–298 (1969).Google Scholar
  29. Randall, L. O.: Pharmacology of methaminodiazepoxide. Dis. nerv. Syst. (Suppl.) 21, 7–10 (1960).Google Scholar
  30. Randall, L. O.: Pharmacology of chlordiazepoxide. Dis. nerv. Syst. (Suppl.) 22, 7–15 (1961).Google Scholar
  31. Rickels, K.: Personal Communication, October 1971.Google Scholar
  32. Salzman, C., Dimascio, A., Shader, R. I., Harmatz, J. S.: Chlordiazepoxide, expectation and hostility. Psychopharmacologia (Berl.) 14, 38–45 (1969).Google Scholar
  33. Scheckel, C. L., Boff, E.: Effects of drugs on aggressive behavior in monkeys, in Neuro-Psychopharmacology V. Proceedings of the Fifth Meeting of the Collegium Internationale Neuro-Psychopharmacologicum. H. Brill, J. O. Cole, P. Deniker, et al., eds., pp. 789–795. Excerpta Medica Series No. 129, Amsterdam 1967.Google Scholar
  34. Senault, B.: Comportement d'aggressivité intraspécifique induit par l'amporphine chez le rat. Psychopharmacologia (Berl.) 18, 271–287 (1970).Google Scholar
  35. Sofia, R. D.: Effects of centrally active drugs on four models of experimentally-induced aggression in rodents. Life Sci. 8, 705–716 (1969).Google Scholar
  36. Tedeschi, R. E., Tedeschi, D. H., Mucha, A., Cook, L., Mattis, P. A., Fellows, E. J.: Effects of various centrally acting drugs on fighting behavior of mice. J. Pharmacol. exp. Ther. 125, 28–34 (1959).Google Scholar
  37. Yen, H. C. Y., Stanger, R. L., Millman, N.: Isolation-induced aggressive behavior in ataratic tests. J. Pharmacol. exp. Ther. 122, 85A (1958).Google Scholar
  38. Yen, H. C. Y., Katz, M. H., Krop, S.: Effects of various drugs an 3,4-dihidroxyphenylalanine (dl-DOPA) induced excitation (aggressive behavior) in mice. Toxicol. appl. Pharmacol. 17, 597–604 (1970).Google Scholar
  39. Valzelli, L., Giacalone, E., Garattini, S.: Pharmacological control of aggressive behavior in mice. Europ. J. Pharmacol. 2, 144–146 (1967).Google Scholar

Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • Alberto DiMascio
    • 1
  1. 1.Department of Mental Health, Commonwealth of Massachusetts and Tufts University School of MedicineBoston State HospitalBoston

Personalised recommendations