Atropine, scopolamine, and Ditran, three centrally active anticholinergic compounds, were administered to 158 normal young males in a dose range broader than any previously reported to study serially their central and peripheral effects. The findings indicate that there are not qualitative differences in the actions of these compounds, but there are differences in potency, relative central affinity, and time course of effects. The toxicity of belladonna-related substances responds well to certain anticholinesterase substances, such as physostigmine, sarin, and THA, but not to others (neostigmine and DFP), nor does it respond to the unrelated drug methylphenidate nor to the phenothiazines. The hallucinations, confusion, and incoherence produced by high doses of anticholinergic compounds seem best classified as simple delirium, rather than as “psychotomimetic” or “psychedelic” syndromes.
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Bliss, C. I.: The statistics of bioassay. New York: Academic Press, Inc. 1952.
Crowell, E. G., Jr., Ketchum, J. S.: The treatment of scopolamine-induced delirium with physostigmine. Clin. Pharmacol. Ther. 8, 409–414 (1967).
Duvoisin, R. C., Katz, R.: Reversal of central anticholinergic syndrome. J. Amer. med. Ass. 206, 1963 (1968).
Engel, G. L., Romano, J.: Delirium, a syndrome of cerebral insufficiency. J. chron. Dis. 9, 260–277 (1959).
Goldner, R. D.: Scopolamine sleep treatment in private practice. Int. J. Neuropsychiat. 3, 234–247 (1967).
Heilbronn, E.: Inhibition of cholinesterases by tetrahydroaminacrin. Acta chem. scand. 15, 1386 (1961).
Heiser, J. F., Gillin, J. C.: The reversal of anticholinergic drug-induced delirium and coma with physostigmine. Amer. J. Psychiat. 127, 1050 (1971).
Kleinwachter, I.: Observations concerning the effectiveness of extract of calabar against atropine poisoning. Berl. klin. Wschr. 1, 369–377 (1864).
Wolff, H. G., Curran, D.: Nature of delirium and allied states: dysergastic reaction. Arch. Neurol. Psychiat. (Chic.) 33, 1175–1215 (1935).
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Ketchum, J.S., Sidell, F.R., Crowell, E.B. et al. Atropine, scopolamine, and Ditran: Comparative pharmacology and antagonists in man. Psychopharmacologia 28, 121–145 (1973). https://doi.org/10.1007/BF00421398
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