Psychopharmacologia

, Volume 38, Issue 3, pp 239–245

Blood and urine levels of N,N-dimethyltryptamine following administration of psychoactive dosages to human subjects

  • J. Kaplan
  • L. R. Mandel
  • R. Stillman
  • R. W. Walker
  • W. J. A. VandenHeuvel
  • J. C. Gillin
  • R. J. Wyatt
Human Pharmacology

Abstract

Psychoactive doses (0.7 mg/kg) of the hallucinogen N,N-dimethyltryptamine (DMT) were administered intramuscularly to 11 normal subjects. A gas chromatographic-mass spectrometric isotope dilution determination of DMT concentrations in whole blood and urine revealed that only a fraction of the injected dose was recovered and the blood DMT concentrations had a very similar time course o the subjectively reported “high”.

Key words

N,N-Dimethyltryptamine Psychotomimetic Schizophrenia Gas Chromatography Mass Spectrometry 

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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • J. Kaplan
    • 1
  • L. R. Mandel
    • 2
  • R. Stillman
    • 1
  • R. W. Walker
    • 2
  • W. J. A. VandenHeuvel
    • 2
  • J. C. Gillin
    • 1
  • R. J. Wyatt
    • 1
  1. 1.Laboratory of Clinical Psychopharmacology, Division of Special Mental Health ResearchIRP, National Institute of Mental Health, Saint Elizabeths HospitalWashington, D.C.
  2. 2.Merck Sharp & Dohme Research LaboratoriesRahway

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