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Antipsychotic drugs stimulate prolactin release

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Antipsychotic drugs have been found to markedly stimulate prolactin secretion in male and female rats. The amount of prolactin released was greater in females than in males. Most non-antipsychotic phenothiazines failed to alter prolactin. These results imply that the dopamine receptor that inhibits prolactin release may be similar to the dopamine receptor involved in the action of antipsychotic drugs.

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Clemens, J.A., Smalstig, E.B. & Sawyer, B.D. Antipsychotic drugs stimulate prolactin release. Psychopharmacologia 40, 123–127 (1974). https://doi.org/10.1007/BF00421361

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Key words

  • Antipsychotic Drugs
  • Prolactin
  • Dopamine