Psychopharmacologia

, Volume 44, Issue 1, pp 47–51 | Cite as

The reliability of the hole-board apparatus

  • Sandra E. File
  • Ann G. Wardill
Animal Studies

Abstract

Two aspects of the reliability of the hole-board apparatus were investigated—the similarity between scores of different samples of the same population on their first exposure to the apparatus, and the test-retest reliability. Rats and mice were given a 5-min exposure to the hole-board and then retested for 5 min after 1, 2 or 8 days.

Male rats and mice showed good initial exposure reliability, whereas the female mouse groups differed significantly. All animals showed a positive test-retest correlation (range 0.31–0.78), but a homogeneous group (e.g. all animals habituating) produced higher correlations (range 0.60–0.99).

Comparison of scores on the two 5-min exposures showed that not all groups showed significant habituation, but the animals exposed to the hole-board for two 10-min periods showed both significant habituation and test-retest reliability.

Key words

Reliability Hole-Board Rats Mice 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Boissier, J. R., Simon, P.: La réaction d'exploration chez la souris. Thérapie 17, 1225–1232 (1962)Google Scholar
  2. Boissier, J. R., Simon, P.: Dissociation de deux composantes dans le comportement d'investigation de la souris. Arch. int. Pharmacodyn. 147, 372–387 (1964)Google Scholar
  3. Boissier, J. R., Simon, P., Lwoff, J. M.: L'utilisation d'une réaction particulière de la souris (méthode de la planche à trous) pour l'étude des médicaments psychotropes. Thérapie 19, 571–589 (1964)Google Scholar
  4. Bradley, D. M. W., Joyce, D., Murphy, E. H., Nash, B. M., Porsolt, R. D., Summerfield, A., Twyman, W. A.: Amphetamine — barbiturate mixture: effects on the behaviour of mice. Nature (Lond.) 220, 187–188 (1968)Google Scholar
  5. Dorr, M., Steinberg, H., Tomkewicz, M., Joyce, D., Porsolt, R. D., Summerfield, A.: Persistence of dose related behaviour in mice. Nature (Lond.) 231, 121–123 (1971)Google Scholar
  6. File, S. E.: Effects of chlorpromazine on exploration and habituation in the rat. Brit. J. Pharmacol. 49, 303–310 (1973)Google Scholar
  7. File, S. E., Day, S.: Effects of time of day and food deprivation on exploratory activity in the rat. Anim. Behav. 20, 758–762 (1972)Google Scholar
  8. File, S. E., Pope, J. H.: The action of chlorpromazine on exploration in pairs of rats. Psychopharmacologia (Berl.) 37, 249–254 (1974)Google Scholar
  9. Gross, C.: General activity. In: Analysis of behavioural change, L. Weiskranz, ed. New York: Harper and Row 1968Google Scholar
  10. Nolan, N. A., Parkes, M. W.: The effects of benzodiazepines on the behaviour of mice on the hole-board. Psychopharmacologia (Berl.) 29, 277–288 (1973)Google Scholar
  11. Simon, P., Fraisse, B., Tillement, J. P., Guernet, M., Boissier, J. R.: Actions de quelques substances psychotropes sur la souris en situation libre soumise à un stimulus extéroceptif. Thérapie 23, 1277–1285 (1968)Google Scholar
  12. Valzelli, L.: The exploratory behaviour in normal and aggressive mice. Psychopharmacologia (Berl.) 15, 232–235 (1969)Google Scholar
  13. Valzelli, L.: Further aspects of the exploratory behaviour in aggressive mice. Psychopharmacologia (Berl.) 19, 91–94 (1971)Google Scholar
  14. Wakeley, H. G., O'Sullivan, D.: Drug effects on mouse exploratory behaviour. Psychonom. Sci. 16, 27–28 (1969)Google Scholar

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • Sandra E. File
    • 1
    • 2
  • Ann G. Wardill
    • 1
    • 2
  1. 1.Pharmacology Department, The School of PharmacyUniversity of LondonEngland
  2. 2.Pharmacology DepartmentRoche Products LimitedEngland

Personalised recommendations