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Liver and intestinal fatty acid binding proteins in control and TGFβ1 gene targeted deficient mice


The effect of transforming growth factor beta-1 (TGFβ1) expression on fatty acid binding proteins was examined in control and two strains of gene targeted TGFβ1-deficient mice. Homozygous TGFβ1-deficient 129 × CF-1, expressing multifocal inflammatory syndrome, had 25% less liver fatty acid binding protein (L-FABP) when compared to control mice. The decrease in L-FABP expression was not due to multifocal inflammatory syndrome since homozygous TGFβ1-deficient/immunodeficient C3H mice on a SLID background had 36% lower liver L-FABP than controls. This effect was developmentally related and specific to liver, but not the proximal intestine, where L-FABP is also expressed. Finally, the proximal intestine also expresses intestinal-FABP (1-FABP) which decreased 3-fold in the TGFβ1-deficient/immunodeficient C3H mice only. Thus, TGFβ1 appears to regulate the expression of L-FABP and I-FABP in the liver and the proximal intestine, respectively.

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liver fatty acid binding protein


intestinal fatty acid binding protein


transforming growth factor beta-1


tumor necrosis factor-α


macrophage inflammatory protein-α


phenylmethyl sulfonyl fluoride


phosphate buffered saline


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Correspondence to Ann B. Kier.

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Fontaine, R.N., Gossett, R.E., Schroeder, F. et al. Liver and intestinal fatty acid binding proteins in control and TGFβ1 gene targeted deficient mice. Molecular and Cellular Biochemistry 159, 149–153 (1996).

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Key words

  • fatty acid binding protein
  • liver
  • intestine
  • growth factor
  • TGFβ1