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Proriatic hair follicle cells

IV Calmodulin levels in freshly isolated and cultured human scalp hair follicle cells

Abstract

Calmodulin levels were measured by radioimmuno-assay in freshly isolated and cultured psoriatic human scalp hair follicle cells. The mean value ± SEM for calmodulin was 1.97±0.15 ng calmodulin μg-1 protein for 16 control subjects whereas calmodulin levels were significantly increased in psoriatic hair follicles, 2.93±0.26 ng calmodulin μg-1 protein (uninvolved skin) for 18 patients and 3.09±0.21 ng calmodulin μg-1 protein for involved skin derived hair follicles for 17 of these patients. In vitro, 3-week-old cultures of psoriatic keratinocytes contained less DNA and more calmodulin per DNA than their normal counterparts. When 6 week-old cultures of psoriatic and control hair follicle keratinocytes were compared, this difference disappeared. These results are related to the state of differentiation of these cultures.

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Lenoir, M.C., Vromans, E., Shroot, B. et al. Proriatic hair follicle cells. Mol Biol Rep 11, 247–252 (1986). https://doi.org/10.1007/BF00419604

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Keywords

  • Control Subject
  • Hair Follicle
  • Follicle Cell
  • Scalp Hair
  • Normal Counterpart