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The effect of induced fever on the biokinetics of norfloxacin and its interaction with probenecid in goats

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Abstract

The kinetic profiles of norfloxacin were evaluated in afebrile, febrile and probenecid pre-treated (70 mg/kg orally) febrile goats after a single intravenous (i.v) dose (5 mg/kg). Fever was induced and maintained for 12 h by injecting Escherichia coli endotoxin (0.2 μg/kg, i.v.) and repeating it in half the dose (0.1 μg/kg) 5 h later. The plasma pharmacokinetic values for norfloxacin were best represented using a two-compartment open model. The peak norfloxacin plasma level of 90.52±3.18 μg/ml attained in the probenecid pre-treated febrile goats was higher than that in the febrile (75.46±0.72 μg/ml) or afebrile goats (62.25±1.23 μg/ml). ClB and K el values were significantly (p<0.01) decreased in febrile compared with afebrile goats. These values were further reduced in febrile goats after probenecid pre-treatment. However, t 1/2β was not affected by the fever-probenecid interaction. Norfloxacin may be used as an infusion with probenecid in caprine diseases where very high plasma levels are required to combat resistant organisms such as Bacteroides.

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Abbreviations

MIC:

minimum inhibitory concentration

LPS:

lipopolysaccharide

i.v.:

intravenous(ly)

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Jha, K., Roy, B.K. & Singh, R.C.P. The effect of induced fever on the biokinetics of norfloxacin and its interaction with probenecid in goats. Vet Res Commun 20, 473–479 (1996). https://doi.org/10.1007/BF00419185

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Keywords

  • fever
  • fluoroquinolone
  • goat
  • norfloxacin
  • pharmacokinetics
  • probenecid