Pharmacologia Clinica

, Volume 1, Issue 2, pp 43–46 | Cite as

Renal effects of a new anabolic steroid (29'038-Ba) in old age

  • A. S. Dontas
  • P. Papanayiotou
  • S. Marketos


The renal effects of 29'038-Ba, a new long-acting injectable anabolic steroid, have been studied in a group of fifteen elderly subjects with normal or impaired renal function. Renal clearances of inulin and endogenous creatinine, the estimated renal blood flow, and the TmPAH were increased by 16.8, 17.2, 17.9 and 35.3 percent respectively after administration of a total of 400 mg of this compound, in contrast to non-significant changes of CPAH and maximal concentrating capacity. No disturbances of liver function were observed in any of the subjects studied. No general side-effects were noticed except for transiently increased libido, reported by three female subjects in the middle of the treatment-period.


Steroid Creatinine Renal Function Liver Function Inulin 
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Die einwirkung eines neuen anabolen steroids (29'038) auf die Nieren älterer patienten


Die Einwirkung von 29'038-Ba, einem neuen langwirkenden injizierbaren anabolen Steroid auf die Nieren, wurde bei einer Gruppe von fünfzehn älteren Patienten mit normaler and beeinträchtigter Nierenfunktion untersucht. Die Nieren-Clearance von Inulin und endogenem Kreatinin, die geschätzte Nierendurchblutung und die TmPAH erhöhten sick um 16,8 bzw. 17,2 bzw. 17,9 bzw. 35,3% nach Verabreichung von insgesamt 400 mg dieses Präparates. Hingegen wurden nur unbedeuteade Veränderungen der CPAH and der maximalen Konzentrationskapazität festgestellt. Irgendwelche Störungen der Leberfunktion konnten bei keinem Patienten beobachtet werden. Auch wurden keine allgemeinen Nebenwirkungen beobachtet, bis auf eine zeitweilig gesteigerte Libido bei drei Patientinnen gegen Mitte der Behandlungszeit.


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  1. Berlyne, G. M.: Endogenous creatinine clearance and the glomerular filtration rate. Amer. Heart J. 70, 143–145 (1965).Google Scholar
  2. Bonsnes, R. W., and H. H. Taussky: On the colorimetric determination of creatinine by Jaffe reaction. J. biol. Chem. 158, 581–591 (1945).Google Scholar
  3. Brandstetter, F., u. F. Schuler: Nierenclearance in der normalen Schwangerschaft. Zentralbl. Gynäk. 76, 181–185 (1954).Google Scholar
  4. Brun, C.: A rapid method for the determination of paraaminohippuric acid in kidney function tests. J. Lab. clin. Med. 37, 955–958 (1951).Google Scholar
  5. Dealvarez, R. R.: Renal glomerulotubular mechanisms during normal pregnancy. I. Glomerular filtration rate, renal plasma flow, and creatinine clearance. Amer. J. Obstet. Gynec. 75, 931–937 (1958).Google Scholar
  6. Desaulles, P. A., and C. Krähenbuhl: Evaluation and mode of action of anabolic steroids, in Gross, F., editor: Protein metabolism. An international sympoposium, pp. 170–184. Berlin: Springer 1962.Google Scholar
  7. Dontas, A. S., N. T. Papanicolaou, P. Pafanayiotou, and B.K. Malamos: Long-term effects of anabolic steroids on renal functions in the aged subject. J. Geront. 22, 268–273 (1967).Google Scholar
  8. Freedman, P., and A.G. Spencer: Testosterone propionate in the treatment of renal failure. Clin. Sci., 16, 11–22 (1957).Google Scholar
  9. Gdørup, S., and J.H. Thaysen: Anabolic steroids in treatment of uraemia. Lancet. 1958 II, 886–887.Google Scholar
  10. Kalliomäki, J. L., A. M. PIRILÄ, and I. Ruikka: A therapeutic trial with ethyl-estrenol in geriatric patients, in Everse, J.W.R., and P. A. Keep, editors: Symposium on anabolic steroids. Acta endocrin. (Kbh.) Suppl. 63, 124–128 (1961).Google Scholar
  11. Kochakian, C.D.: Comparison of protein anabolic property of various androgens in the castrated rat. Amer. J. Physiol. 160, 53–56 (1950).Google Scholar
  12. Korenchevsky, V., and M.A. Ross: The kidneys and sex hormones. Brit. Med. J. 1940 I, 645–647.Google Scholar
  13. Landau, R. L., and A. Kappas: Anabolic hormones in hyperparathyroidism. Ann. Int. Med. 62, 1223–1233 (1965).Google Scholar
  14. Lattimer, J.K.: The action of testosterone propionate upon the kidneys of rats, dogs and men. J. Urol. 48, 778–794 (1942).Google Scholar
  15. Merrill, J. P.: The treatment of renal failure, New York: Grune & Stratton 1965.Google Scholar
  16. O'Connor, W. J.: Renal function. London: A. Arnold Ltd. 1962.Google Scholar
  17. Overbeek, G.A., J. Vander Vies, and J. Visser: Evaluation of long-acting anabolic steroids, in Gross, F., editor: Protein metabolism. An international symposium, pp. 185–195. Berlin: Springer 1962.Google Scholar
  18. Rosenthal, S. M., and E. C. White: Clinical applications of the bromsulphalein test for hepatic function. J. Amer. med. Ass. 84, 1112–1114 (1925).Google Scholar
  19. Schreiner, G. E.: Determination of inulin by means of resorcinol. Proc. Soc. exp. Biol. 74, 117–120 (1950).Google Scholar
  20. Sigler, M. H., and B. Issekutz, Jr.: Effects of anabolic steroids in chronic renal failure. Arch. intern. Med. 120, 408–416 (1967).Google Scholar
  21. Thaysen, J. H.: Anabolic steroids in the treatment of renal failure, in Gross, F., editor: Protein metabolism. An international symposium, pp.450–478. Berlin: Springer 1962.Google Scholar
  22. de Wardener, H. E.: Vasopressin tannate in oil and the urine concentration test. Lancet. 1956 I, 1037–1038.Google Scholar
  23. Welsh, C.A., A. Rosenthal, M.T. Duncan, and H.C. Taylor: Testosterone propionate and renal function. Amer. J. Physiol. 137, 338–342 (1942.)Google Scholar

Copyright information

© Springer-Verlag 1968

Authors and Affiliations

  • A. S. Dontas
    • 1
  • P. Papanayiotou
    • 1
  • S. Marketos
    • 1
  1. 1.Department of Clinical TherapeuticsUniversity of AthensAthensGreece

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