Co-culturing with origin-defective SV40 DNA-injected transformants, we succeeded in activating the limited growth potential of late-phase-II fibroblasts from patients with Werner's syndrome (WS cells). Residual life spans of three WS cell lines increased 2.3–5.6 fold. Co-culture with normal IMR-90 cells showed variable effects on different WS cell lines.
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Ohno, T., Yamaguchi, N. Life span elongation of Werner's syndrome fibroblasts by co-culture with origin-defective SV-40 DNA transformed cells. Hum Genet 68, 209–210 (1984). https://doi.org/10.1007/BF00418390
- Internal Medicine
- Metabolic Disease
- Life Span
- Variable Effect
- Limited Growth