Neurosurgical Review

, Volume 18, Issue 2, pp 95–100 | Cite as

Treatment of severe intraventricular hemorrhage by intraventricular infusion of urokinase

  • Hidayet Akdemir
  • Ahmet Selçuklu
  • Aydin Paşaoğlu
  • I Suat Öktem
  • Ikram Kavuncu
Original Articles


During the last three years, seven patients with severe intraventricular hemorrhage admitted to our clinic were treated with direct intraventricular infusion of urokinase. In each case, hemorrhage extended into the entire ventricular cavity and cast formation as well as an expansion of third and fourth ventricles were found. On the average, both the third and fourth ventricles became clear on the third day and the lateral ventricle on the ninth day after hemorrhage. Five of the seven patients showed good recovery or only moderate disability, and two died. Infection, convulsion, rebleeding, and peripheral or secondary hemorrhage due to the side effects of urokinase was not encountered during therapy.

We conclude that this procedure can be applied effectively and safely in severe intraventricular hemorrhage.


Intraventricular hemorrhage urokinase ventricular drainage 


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Copyright information

© Walter de Gruyter & Co 1995

Authors and Affiliations

  • Hidayet Akdemir
    • 1
  • Ahmet Selçuklu
    • 1
  • Aydin Paşaoğlu
    • 1
  • I Suat Öktem
    • 1
  • Ikram Kavuncu
    • 1
  1. 1.Department of NeurosurgeryErciyes University, School of MedicineKayseriTurkey

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