Bioprocess Engineering

, Volume 13, Issue 5, pp 245–250 | Cite as

A fedbatch strategy for optimal red pigment production by monascus ruber

  • A. Laurence Santerre
  • I. Queinnec
  • P. J. Blanc


According to the measurement of the pigment production and some material balance treatments, the monosodium glutamate (MSG), which represents a main substrate involved in the production of red pigment by Monascus ruber, is recovered on-line. Fedbatch operation then represents an alternative for increasing the production of pigment. A nonlinear quotient control scheme is expressed to regulate the monosodium glutamate substrate at an optimal value determined from batch studies.


Waste Water Glutamate Water Management Water Pollution Material Balance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Symbols


absorbancy units (AU)


lightness parameter


red pigment quantity (Gmol)


fermentor active volume (1)


empirical coefficient


red pigment molecular weight (g)


elementary matrix


pseudo-inverse elementary matrix


conversion rates vector (g· l−1·h−1)


measured part of the elementary matrix


measured conversion rates vector


non-measured part of the elementary matrix


non-measured conversion rates vector


fictitious controller input


fictitious controller output


controller input


controller output


controller setpoint


controller parameter


controller parameter


time iteration


monosodium glutamate concentration (g·l−1)


monosodium glutamate initial quantity (g)


total quantity of monosodium glutamate added (g)


total quantity of monosodium glutamate consumed (g)


monosodium glutamate molecular weight (g)


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • A. Laurence Santerre
    • 1
  • I. Queinnec
    • 2
  • P. J. Blanc
    • 1
  1. 1.Centre de Bioingénierie Gilbert Durand, URA 544, Equipe associée INRADGBA-INSA, Complexe scientifique de rangueilToulouse cedexFrance
  2. 2.Laboratoire d'Analyse et d'Architecture des Systèmes-CNRSToulouse cedexFrance

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