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Antibiotic prophylaxis in penetrating injuries of the eye

  • A. B. Parunović
  • B. A. Popović
Article

Summary

In a specially developed experimental model of an infected penetrating eye injury the importance of time and mode of antibiotic administration in the prophylaxis of post-traumatic eye infection was evaluated.

It was concluded that the early administration of an antibiotic to which infecting organisms are sensitive can prevent the development of an inflammatory reaction in the majority of injured eyes.

The late administration of the same antibiotic (6 h after injury) has no effect at all. Subconjunctival injection was found to be superior to intramuscular if the antibiotic was given at a similar time after injury.

The results of this experiment stress the importance of very early antibiotic administration in the prophylaxis of an infection in penetrating eye injuries.

Keywords

Public Health Experimental Model Inflammatory Reaction Antibiotic Prophylaxis Similar Time 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Zusammenfassung

Untersuchungen über die antibiotische Prophylaxe gegen eine post-traumatische Augeninfektion nach perforierenden Verletzungen. Es zeigte sich, daß eine frühe Verabreichung von Antibiotika, gegen welche die Erreger sensibel sind, in der Mehrzahl der Fälle eine Infektion verhütet. Eine späte Gabe desselben Antibiotikums (6 h nach der Verletzung) bleibt wirkungslos. Subconjunctivale Injektionen sind intramuskulären überlegen. Versuche bestätigen die Bedeutung der möglichst frühen Antibiotikagabe zur Prophylaxe nach perforierenden Augenverletzungen.

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References

  1. Andersen, W. D.: Prophylactic antibiotics and endophthalmitis in Vietnam. Amer. J. Ophthal. 75, 481–485 (1973)Google Scholar
  2. Hvatova, A. V.: Clinical treatment of eye trauma (in Russian). Moskva: Medgiz 1964Google Scholar
  3. Krasnov, M. L., Berezinskaia, D. I., Fridman, C. J.: Penetrating eye injuries (in Russian). Leningrad: Medgiz 1951Google Scholar
  4. Maicuck, J. F.: Antibiotics in Ophthalmology (in Russian). Moskva: Medicina 1973Google Scholar
  5. Schenck, A. G., Peyman, G. A.: Lincomycin by direct intravitreal injection in the treatment of experimental bacterial endophthalmitis. Graefes Arch. Ophthal. 190, 218–291 (1974)Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • A. B. Parunović
    • 1
    • 2
  • B. A. Popović
    • 1
  1. 1.University Eye ClinicBelgrade
  2. 2.Očna klinikaBelgradeYugoslavia

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