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Relationship between morphologic features and hardness of the subchondral bone of the medial tibial condyle in the normal state and in osteoarthritis and rheumatoid arthritis

  • Paul Lereim
  • Ian F. Goldie
Article

Summary

In osteoarthritis and rheumatoid arthritis the hardness of the subchondral bone of the medial tibial plateau is lower than in normals. In order to further analyse this study of the morphologic characteristics in bone from the mentioned region was carried out in 22 normals, 14 osteoarthritis and 12 rheumatoid arthritis. Specimens from these groups were subjected to a radiologic assay, a light microscopic investigation and an evaluation of the occurrence of intraosseous lipids. The normals showed a remarkable integrity of the subchondral trabecular network with advancing age only with slight osteoporosis and occasional sclerosis. In osteoarthritis there were osteoporosis, osteolysis, sclerosis and osteophytes all in good correlation to the grade of osteoarthritis present. In rheumatoid arthritis there were areas of rarefaction, fractures of the trabeculae, sclerosis and invasion of granulation tissue. The radiologic appearance corresponded well with the morphologic observation. No abnormal presence of lipids was encountered. This investigation supports the concept that the hardness of the subchondral bone of the medial tibial plateau much depends on the morphologic structure of the bone.

Keywords

Rheumatoid Arthritis Osteoporosis Osteoarthritis Subchondral Bone Radiologic Appearance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Zusammenfassung

Die Härte im subchondralen Knochen des medialen Tibiakondyls ist viel höher in normalem Zustand verglichen mit der bei Arthrosis deformans und rheumatoider Arthritis. Diese Verhältnisse sind analysiert gegen den Hintergrund von morphologischen Veränderungen in Präparaten der Normalfälle und solchen bei Arthrosis deformans und rheumatoider Arthritis mit radiologischen, mikroskopischen und lipidchemischen Methoden. Die Untersuchungen zeigen 12 Normalfälle, 14 Arthrosis deformans-Fälle und 12 Rheumatoide Arthritis-Fälle. Die Normalfälle haben eine offenbare Integrität des subchondralen Trabekelsystems gezeigt. Mit steigendem Alter waren nur mäßige Osteoporosis und Sklerosis sichtbar. Bei der Arthrosis deformans waren in guter Korrelation mit dem Grad der Arthrosis nach Collins Osteoporosis, Osteolysis, Sklerosis und Osteophyten sichtbar. Bei rheumatoider Arthritis waren Cysten, trabekuläre Frakturen, Sklerosis und Invasion von Granulationsgewebe sichtbar. Die röntgenologischen Befunde haben wohl mit den morphologischen Verteilungen übereinzustimmen. Kein abnormes Vorkommen von Lipiden wurde beobachtet. Diese Untersuchungen zeigen, daß die Härte im subchondralen Knochen sehr abhängig von der morphologischen Struktur des Knochens ist.

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Copyright information

© J. F. Bergmann 1975

Authors and Affiliations

  • Paul Lereim
    • 1
    • 2
  • Ian F. Goldie
    • 1
  1. 1.Department of Orthopaedic Surgery IIUniversity of GöteborgSweden
  2. 2.Sophies Minde Ortopedisk HospitalUniversity of OsloOsloNorway

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