Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Effect of heparin on histaminase in guinea pig skin

  • 18 Accesses

  • 1 Citations

This is a preview of subscription content, log in to check access.


  1. Baylin, S. B., Beaven M. A., Krauss R. M., Keiser, H. R.: Response of plasma histaminase activity to small doses of heparin in normal subjects and patients with hyperlipoproteinemia. J. Clin. Invest. 52, 1985–1993 (1973)

  2. Bergman, H., Carlström, A., Gustavsson, I., Lindsten, J.: Protein-heparin complexes as a cause of artificial enzyme polymorphism. Scand. J. Clin. Lab. Invest. 27, 341–344 (1971)

  3. Giertz, H., Hahn, F., Krull, P., Albert, U.: Histamine liberating and anticoagulant activity of heparin released in anaphylactic shock in the guinea pig. Int. Arch. Allergy. 33, 306–312 (1968)

  4. Hahn, F., Kretzschman, R., Teschendorf, H. J., Mitze, R.: Role of histaminase (diamine oxidase) in disappearance of plasma histamine in anaphylaxis and after histamine injection. Int. Arch. Allergy 39, 449–458 (1970)

  5. Hahn, F., Schmutzler, W., Seseke, G., Giertz, H., Bernauer, W.: Histaminfreisetzung durch Heparin und Protamin beim Meerschweinchen. Biochem. Pharmacol. 15, 155–160 (1966)

  6. Schmutzler, W., Goldschmidt, O., Bethge, K., Knop, J.: The release of guinea pig liver histaminase and some of its properties. Int. Arch. Allergy 36, 45–55 (1969)

  7. Yamamoto, S., Francis, D., Greaves, M. W.: Enzymic histamine metabolism in guinea pig skin and its role in immediate hypersensitivity reactions. Clin. Exp. Immunol. 26, 583–589 (1976)

Download references

Author information

Correspondence to Shoso Yamamoto.

Additional information

This work was supported by Scientific Research Grant from the Japanese Ministry of Education (D, No. 467179)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Yamamoto, S., Yoshikuni, K. & Yamura, T. Effect of heparin on histaminase in guinea pig skin. Arch Dermatol Res 267, 101–104 (1980). https://doi.org/10.1007/BF00416929

Download citation


  • Public Health
  • Heparin