Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Absence of indoleamine-accumulating neurons in the retina of humans and cynomolgus monkeys

Summary

Indoleamine-accumulating neurons have previously been detected in cats, rabbits, goldfish, chicken, pigeons, and Cebus monkeys, and were therefore also looked for in humans and an Old World monkey, Cynomolgus irus. The monkey eyes were injected intravitreally with 50 μg 5,6-dihydroxytryptamine, 5 μg α-methylnoradrenaline, or both drugs simultaneously. The human retinas were incubated in either drug.

Previous observations on the distribution of dopaminergic neurons were confirmed in the two species, but no indoleamine-accumulating neurons were detected. The result emphasizes the similarity between human and Old World monkey retinas and contrasts them with the retina of the New World monkeys.

This is a preview of subscription content, log in to check access.

References

  1. Ames, A.: Studies of morphology, chemistry and function in isolated retina. In: Biochemistry of the Retina, Graymore, ed., pp. 22–30. London-New York: Academic Press 1965

  2. Bertler, Å., Falck, B., Rosengren, E.: The direct demonstration of a barrier mechanism in the brain capillaries. Acta Pharmacol. Toxicol. 20, 317–321 (1963)

  3. Björklund, A., Falck, B., Owman, Ch.: Fluorescence microscopic and microspectrofluorometric techniques for the cellular localization and characterization of biogenic amines. In: Methods of Investigative and Diagnostic Endocrinology, J.E. Rall and I. Kopin, eds., pp. 318–368. Amsterdam-London-New York: North-Holland 1972

  4. Boycott, B.B., Dowling, J.E., Fisher, S.K., Kolb, H., Laties, A.M.: Interplexiform cells of the mammalian retina and their comparison with catecholamine-containing retinal cells. Proc. R. Soc. Lond. [Biol.] 191, 353–368 (1975)

  5. Corrodi, H., Jonsson, G.: The formaldehyde fluorescence method for the histochemical demonstration of biogenic monoamines. A review on the methodology. J. Histochem. Cytochem. 15, 65–78 (1967)

  6. Dowling, J.E., Ehinger, B.: Synaptic organization of the amine-containing interplexiform cells of the goldfish and Cebus monkey retinas. Science 188, 270–273 (1975)

  7. Dowling, J.E., Ehinger, B.: The interplexiform cell system: 1. Synapses of the dopaminergic neurons of the goldfish retina. Proc. R. Soc. Lond. [Biol.] 201, 7–26 (1978)

  8. Ehinger, B.: Adrenergic nerves to the eye and to related structures in man and in the Cynomolgus monkey. Invest. Ophthalmol. 5, 42–52 (1966)

  9. Ehinger, B.: Biogenic monoamines and amino acids as retinal neurotransmitters. In: Frontiers in Visual Sciences, S.J. Cool and E.L. Smith, III, eds. Berlin-Heidelberg-New York: (in press 1978)

  10. Ehinger, B., Falck, B.: Adrenergic retinal neurons of some New World monkeys. Z. Zellforsch. 100, 364–375 (1969a)

  11. Ehinger, B., Falck, B.: Morphological and pharmacohistochemical characteristics of adrenergic retinal neurons of some mammals. Albrecht von Graefes Arch. Klin. Ophthalmol. 178, 295–305 (1969b)

  12. Ehinger, B., Florén, I.: Indoleamine accumulating neurons in the retina of rabbit, cat and goldfish. Cell Tissue Res. 175, 37–48 (1976)

  13. Ehinger, B., Florén, I.: Quantitation of the uptake of indoleamines and dopamine in the rabbit retina. Exp. Eye Res. 26, 1–11 (1978a)

  14. Ehinger, B., Florén, I.: Chemical removal of indoleamine accumulating terminals in rabbit and goldfish retina. Exp. Eye Res. 26, 321–328 (1978b)

  15. Florén, I.: Indoleamine accumulating neurons in the retina of chicken and pigeon. A comparison with dopaminergic neurons. Acta Ophthalmol. (in press 1978)

  16. Florén, I., Hansson, H.C.: Aspects on 5-hydroxytryptamine as a neurotransmitter in the retina of rabbit and chicken Invest. Ophthalmol. (in press 1978)

  17. Iversen, L.L., Callingham, B.A.: Adrenergic transmission. In: Fundamentals of Biochemical Pharmacology, Z.M. Bacq, ed., pp. 253–305. Oxford-New York-Toronto-Sydney-Braunschweig: Pergamon Press 1971

  18. Kolb, H., West, R.W.: Synaptic connections of the interplexiform cell in the retina of the cat. J. Neurocytol. 6, 155–170 (1977)

  19. Laties, A.M., Jacobowitz, D.: A comparative study of the autonomic innervations of the eye in monkey, cat and rabbit. Anat. Rec. 156, 383–396 (1966)

  20. Lindvall, O.: The glyoxylic acid fluorescence histochemical method for monoamines. Thesis, University of Lund 1974

  21. Oyster, C.W., Takahashi, E.S.: Interplexiform cells in the rabbit retina. Proc. R. Soc. Lond. [Biol.] 197, 477–482 (1977)

  22. Ramon y Cajal, S.: The vertebrate retina. In: The Vertebrate Retina. Principles of Structure and Function, R.W. Rodieck, ed., Appendix 1. San Francisco: Freeman 1893/1973

  23. Ritzén, M.: Quantitative fluorescence microspectrophotometry of catecholamine-formaldehyde products. Exp. Cell Res. 44, 505–520 (1966)

  24. Shaskan, E.G., Snyder, S.H.: Kinetics of serotonin accumulation into slices from rat brain: Relationship to catecholamine reuptake. J. Pharmacol. Exp. Ther. 175, 404–418 (1970)

Download references

Author information

Correspondence to I. Florén.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ehinger, B., Florén, I. Absence of indoleamine-accumulating neurons in the retina of humans and cynomolgus monkeys. Albrecht von Graefes Arch. Klin. Ophthalmol. 209, 145–153 (1979). https://doi.org/10.1007/BF00414607

Download citation

Keywords

  • Public Health
  • Retina
  • Dopaminergic Neuron
  • Cynomolgus Monkey
  • World Monkey