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Psychopharmacologia

, Volume 29, Issue 3, pp 197–201 | Cite as

Control of morphine-withdrawal hypothermia by conditional stimuli

  • Mark Roffman
  • Cherjerla Reddy
  • Harbans Lal
Animal Studies

Abstract

Male rats were given increasing doses of morphine sulfate to cause addiction. Each injection was paired with a bell. After a number of pairings, the bell acquired conditional-stimulus property in that, like morphine, it prevented withdrawal hypothermia during 72 h of withholding morphine. In another group the withdrawal hypothermia was precipitated by withholding of morphine injections. The bell reversed that hypothermia.

Key words

Narcotic Addiction Conditional Stimulus Hypothermia Narcotic Withdrawal Morphine 

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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • Mark Roffman
    • 1
  • Cherjerla Reddy
    • 1
  • Harbans Lal
    • 1
  1. 1.Department of Pharmacology and Toxicology and Department of PsychologyUniversity of Rhode IslandKingston

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