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Prognostic significance of the patient's sex, tumor site, and mitotic rate in thin (≤1.5 mm) melanoma

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Summary

Patients who died of a melanoma thinner than 1.5mm within 96 months (group 1, n=60) were compared with those having a tumor of the same thickness who had not died in this time period (Group 2, n=300). Both groups were investigated with respect to differences in patients sex and age and to thickness, diameter, exophytic growth, and site of the melanoma as well as the number of mitoses/mm2 of tumor area. Relatively speaking, more men than women died of a thin melanoma: in Group 1 (deceased) there were 32 men and 28 women, in Group 2 (alive) 58 men and 242 women. The better survival rate of females did not depend on the difference in the predominating melanoma locations (♀face and legs; ♂ trunk): in both sites, on the legs and on the trunk, women had a significantly higher 8-year survival rate than men with equally thick tumors. Furthermore, melanomas on the arms and legs of females had a better prognosis than those on the trunk and face. Both the patient's sex and the tumor site seem to influence the survival of melanoma patients. Only in men was the median of mitoses/mm2 of tumor area found to be higher in the first group (2.2) than in the second group (0.75). In women, no marked difference in the mitotic count was found (Group 1:1.1; Group 2:1.15).

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References

  1. 1.

    Ariel IM (1982) Malignant melanoma of the trunk: A retrospective review of 1128 patients. Cancer 49:1070–1078

  2. 2.

    Balch CM, Murad TM, Soong S-J, Ingalls AL, Halpern NB, Maddox WA (1978) A multifactorial analysis of melanoma: Prognostic histopathological features comparing Clark's and Breslow's staging methods. Ann Surg 188:732–742

  3. 3.

    Breslow A (1975) Tumor thickness, level of invasion and node dissection in stage I cutaneous melanoma. Ann Surg 182:572–575

  4. 4.

    Breslow A (1980) Prognosis in cutaneous melanoma. Tumor thickness as a guide to treatment. Patholol Annu 15/I:1–22

  5. 5.

    Cascinelli N, Morabito A, Bufalino R, Van der Esch EP, Preda F, Vaglini M, Rovini D, Orefice S (1980) Prognosis of stage I melanoma of the skin. WHO collaborating centres for evaluation of methods of diagnosis and treatment of melanoma. Int J Cancer 26:733–739

  6. 6.

    Davis NC, McLeod GR, Beardmore GL, Little JH, Quinn RL, Holt J (1976) Primary cutaneous melanoma: a report from the Queensland melanoma project. CA 26:80

  7. 7.

    Day CL, Sober AJ, Fitzpatrick TB, Lew RA, Mihm MC (1980) Prognosis in malignant melanoma. Am Acad Dermatol 3:525–526

  8. 8.

    Day CL, Mihm MC, Sober AJ, Haris MN, Kopf AW, Fitzpatrick TB, Lew RA, Harrist TJ, Golomb FM, Postel A, Hennessey P, Gumport SL, Rahe JW, Malt RA, Cosimi AB, Wood WC, Roses DF, Gorstein F, Rigel D, Friedman RJ, Mintzis MM (1982) Prognostic factors for melanoma patients with lesions 0.76–1.69 mm in thickness. Ann Surg 195:30–34

  9. 9.

    Eldh J, Boeryd N, Peterson L-E (1978) Prognostic factors in cutaneous malignant melanoma in stage I. A clinical, morphological and multivariate analysis. Scand J Plast Reconstr Surg 12:243–255

  10. 10.

    Esch EP van der, Heite HJ, Kuehnl-Petzoldt Ch (1974) A model of punchcard-coded description of histological structures in the primary cutaneous melanoma. EVD Med Biol 5:43–49

  11. 11.

    Esch EP van der, Cascinelli N, Preda F, Morabito A, Bufalino R (1981) Stage I melanoma of the skin: evaluation of prognosis according to histologic characteristics. Cancer 48:1668–1673

  12. 12.

    Grond K (1979) Zur Prognose des Melanomalignoms. Z Hautkr 54:559–570

  13. 13.

    Heite HJ (1975) On the usual “mortality curve” in the case of the malignant melanoma. — Interpretation and consequences. Arch Dermatol Res 252:81–82

  14. 14.

    Heite HJ (1981) Ergebnisse der Arbeitsgemeinschaft Malignes elanom der Deutschen Forschungsgemeinschaft. Hautarzt [Suppl V] 32:11–19

  15. 15.

    Huvos AG, Shab JP, Mike V (1974) Prognostic factors in cutaneous malignant melanoma. A comparative study of longterm and short-term survivors. Hum Pathol 5:347–357

  16. 16.

    Kapelanski DP, Block GE, Kaufman M (1979) Characteristics of the primary lesion of malignant melanoma as a guide to prognosis and therapy. Ann Surg 189:225–235

  17. 17.

    Kuehnl-Petzoldt Ch, Wiebelt H, Berger H (1983) Malignes Melanom: Prognostische Beurteilung durch Korrelationskoeffizienten. Hautarzt 34:398–402

  18. 18.

    Kuehnl-Petzoldt Ch, Wiebelt H, Berger H, Wagner G (1983) A proposal for staging malignant melanoma. Arch Dermatol Res 275:255–256

  19. 19.

    Kuehnl-Petzoldt Ch, Wiebelt H, Berger H (1983) Prognostic groups of patients with stage I melanoma. Arch Dermatol 119: 816–819

  20. 20.

    Kuehnl-Petzoldt Ch, Wiebelt H, Berger H (1984) In what sense are break-points prognostic in malignant melanoma. Am J Dermatopathol (in press)

  21. 21.

    Magnus K (1977) Prognosis in malignant melanoma of the skin. Significance of stage of disease, anatomical site, sex, age and period of diagnosis. Cancer 40:389–397

  22. 22.

    Magnus K (1981) Habits of sun exposure and risk of malignant melanoma: an analysis of incidence rates in Norway 1955–1977 by cohort, sex, age, and primary tumor site. Cancer 48:2329–2335

  23. 23.

    McGovern VJ, Shaw HM, Milton GW, Farago GA (1979) Prognostic significance of the histological features of malignant melanoma. Histopathology 3:385–393

  24. 24.

    Pathak DR, Samet JM, Howard CA, Key CR (1982) Malignant melanoma of the skin in New Mexico 1969–1977. Cancer 7:1440–1446

  25. 25.

    Pondes S, Hunter JAA, White H, McIntyre MA, Prescott RJ (1981) Cutaneous malignant melanoma in South-east Scotland. Quarterly J Med, New Series L, 50:103–121

  26. 26.

    Rampen F (1980) Malignant melanoma: sex differences in survival after evidence of distant metastasis. Br J Cancer 42:52–57

  27. 27.

    Roberts G, Martyn, Dobson AJ, McCarthy WH (1981) Tumor thickness and histological type in malignant melanoma in New South Wales, Australia, 1970–76. Pathology 13:763–770

  28. 28.

    Schmoeckel Ch, Braun-Falco O (1978) Prognostic index in malignant melanoma. Arch Dermatol 114:871–873

  29. 29.

    Schmoeckel Ch, Bockelbrink A, Bockelbrink H, Koutsis J, Braun-Falco O (1983) Low and high risk malignant melanoma I. Evaluation of clinical and histological prognosticators in 585 cases. Eur J Cancer Clin Oncol 19:227–235

  30. 30.

    Schmoeckel Ch, Bockelbrink A, Bockelbrink H, Kistler H, Braun-Falco O (1983) Low and high risk malignant melanoma. III. Prognostic significance of the resection margin. Eur J Cancer Clin Oncol 19:245–249

  31. 31.

    Shaw HM, McGovern VJ, Milton GW, Fargo GA, McCarthy WH (1981) Histologic features of tumors and the female superiority in survival from malignant melanoma. Cancer 45:1604–1608

  32. 32.

    Shaw HM, McGovern VJ, Milton GW, Farago GA, McCarthy WH (1981) Malignant melanoma: influence of site of lesion and age of patient in the female superiority in survival. Cancer 46:2731–2735

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Correspondence to C. Kuehnl-Petzoldt.

Additional information

Supported by the Deutsche Forschungsgemeinschaft

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Kuehnl-Petzoldt, C., Keil, H. & Schoepf, E. Prognostic significance of the patient's sex, tumor site, and mitotic rate in thin (≤1.5 mm) melanoma. Arch Dermatol Res 276, 151–155 (1984). https://doi.org/10.1007/BF00414011

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Key words

  • Malignant melanoma
  • Prognosis
  • Mitotic count
  • Tumor site
  • Patient's sex