Archives of Microbiology

, Volume 145, Issue 1, pp 104–106 | Cite as

Effect of anticalmodulin drugs on the action of yeast α factor pheromone

  • Teresa Ruiz
  • Luis Rodriguez
Short Communication


Saccharomyces cerevisiae α factor pheromone arrest growth of cells of the a mating type (MAT a) at the G1 phase of the cell cycle. When treatment of MAT a cells with α factor was carried out in the presence of anticalmodulin drugs, trifluoperazine or chlorpromazine, the extent of cell growth arrest induced by α factor was reduced or even became undetectable. These results lend support to the hypothesis that calmodulin plays a role as mediator in the action of α factor on MAT a cells.

Key words

Saccharomyces cerevisiae α Factor Trifluoperazine Chlorpromazine Calmodulin 



mating type


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Teresa Ruiz
    • 1
  • Luis Rodriguez
    • 1
  1. 1.Cátedra de Microbiologia, Facultad de FarmaciaUniversidad de La LagunaTenerifeCanary Islands, Spain

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